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Effects of Chitosan Derivative N-[(2-Hydroxy-3-Trimethylammonium)Propyl]Chloride on Anticoagulant Activity of Guinea Pig Plasma

  • PHARMACOLOGY AND TOXICOLOGY
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Bulletin of Experimental Biology and Medicine Aims and scope

Intravenous injection of protamine sulfate or quarternized chitosan derivative to guinea pigs after injection of 70 aIIa U/kg non-fractionated heparin shortened plasma clotting time (shown by partial activated thromboplastin time, thrombin time, and prothrombin time). Intravenous injection of protamine sulfate or quarternized chitosan derivative to guinea pigs after injection of 1 mg/kg (100 aXa U/kg) low-molecular-weight heparin (clexane) led to shortening of plasma clotting time in the ReaClot Heparin test and to prolongation of plasma amidolytic activity in the factor Xa chromogenic substrate test.

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Authors and Affiliations

  1. National Research Center for Hematology, Ministry of Health of the Russian Federation, Moscow, Russia

    N. N. Drozd

  2. Institute of Bioengineering, Federal Research Centre “Fundamentals of Biotechnology”, Russian Academy of Sciences, Moscow, Russia

    B. Ts. Shagdarova, A. V. Il’ina & V. P. Varlamov

Authors
  1. N. N. Drozd
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  2. B. Ts. Shagdarova
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  3. A. V. Il’ina
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  4. V. P. Varlamov
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Corresponding author

Correspondence to N. N. Drozd.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 163, No. 3, pp. 321-324, March, 2017

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Drozd, N.N., Shagdarova, B.T., Il’ina, A.V. et al. Effects of Chitosan Derivative N-[(2-Hydroxy-3-Trimethylammonium)Propyl]Chloride on Anticoagulant Activity of Guinea Pig Plasma. Bull Exp Biol Med 163, 340–343 (2017). https://doi.org/10.1007/s10517-017-3799-6

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  • DOI: https://doi.org/10.1007/s10517-017-3799-6

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