Pial arteries of different diameter were studied in intact rats and after 6-month modeling of chronic tobacco smoking in rats. Expression of tachykinin NK1 receptors in pial arteries was studied by biomicroscopy and immunohistochemical methods. Chronic tobacco smoking induced considerable reorganizations of the arterial bed. The intensity of changes depended on the diameter of vessels. In small pial vessels that directly participate in the blood supply to the brain, pronounced vasodilatation and enhanced expression of NK1 receptors in the endothelium mediating the effects of substance P were observed; the number of these vessels also increased. The intensity of the response to tobacco smoke components decreased with increasing vessel diameter.
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Afanasiev AA, Chertok VM. Application of automated system of image analysis allegromc for quantitative biomicroscopy of microcirculatory channel. Tikhookean. Med. Zh. 2004;(2):82-86. Russian.
Kotsiuba AE, Babich EV, Chertok VM. Vasomotor innervation of the human pia mater in arterial hypertension. Zh. Nevrol. Psikhiatr. im. S. S. Korsakova. 2009;109(9):56-62. Russian.
Motavkin PA, Chertok VM. Brain innervation. Tikhookean. Med. Zh. 2008;(3):11-23. Russian.
Nevzorova VA, Zaharchuk NV, Agafonova IG, Sarafanova NS. Features of arterial hypertension and smoking-related cerebrovascular dysfunction. Tikhookean. Med. Zh. 2013;(4):9-16. Russian.
Chertok VM, Kotsyuba AYe, Bespalova YeV. Microvessel reaction of some organs to laser radiation. Morfologiya. 2008;133(2):150-151. Russian.
Chertok VM, Startseva МS, Kotsyuba AYe. The application of a “pixel method’ for the quantitative assessment of the results of the histochemical studies. Morfologiya. 2012;142(5):71-75. Russian.
Bruno G, Tega F, Bruno A, Graf U, Corelli F, Molfetta R, Barucco M. The role of substance P in cerebral ischemia. Int. J. Immunopathol. Pharmacol. 2003;16(1):67-72.
Corrigan F, Vink R, Turner R.J. Inflammation in acute CNS injury: a focus on the role of substance P. Br. J. Pharmacol. 2016;173(4):703-715.
Donkin JJ, Nimmo AJ, Cernak I, Blumbergs PC, Vink R. Substance P is associated with the development of brain edema and functional deficits after traumatic brain injury. J. Cereb. Blood Flow Metab. 2009;29(8):1388-1398.
Lewis KM, Turner RJ, Vink R. Blocking neurogenic inflammation for the treatment of acute disorders of the central nervous system. Int. J. Inflam. 2013;2013. ID 578480. doi: 10.1155/2013/578480.
Nevzorova VA, Zakharchuk NV, Belushkina TR, Agafonova IG, Gilifanov EA. Endothelium-dependent and endothelium-independent cerebral vessel reactions in a chronic smoking model. Int. J. Biomed. 2011;1(2):103-107.
Ribeiro-da-Silva A, Hökfelt T. Neuroanatomical localisation of Substance P in the CNS and sensory neurons. Neuropeptides. 2000;34(5):256-271.
Severini C, Improta G, Falconieri-Erspamer G, Salvadori S, Erspamer V. The tachykinin peptide family. Pharmacol. Rev. 2002;54(2):285-322.
Turner RJ, Vink R. NK1 tachykinin receptor treatment is superior to capsaicin pre-treatment in improving functional outcome following acute ischemic stroke. Neuropeptides. 2014;48(5):267-272.
Zheng H, Liu Y, Huang T, Fang Z, Li G, He S. Development and characterization of a rat model of chronic obstructive pulmonary disease (COPD) induced by sidestream cigarette smoke. Toxicol. Lett. 2009;189(3):225-234.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 163, No. 3, pp. 290-293, March, 2017
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Zakharchuk, N.V., Chertok, V.M., Nevzorova, V.A. et al. Effects of Chronic Tobacco Smoking on the Distribution of Tachykinin Receptors in Rat Pial Arteries. Bull Exp Biol Med 163, 313–316 (2017). https://doi.org/10.1007/s10517-017-3792-0
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DOI: https://doi.org/10.1007/s10517-017-3792-0