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Dynamics of the Development of Depressive-Like State in Rats Stressed by Chronic Exposure of Ultrasound of Variable Frequency

  • GENERAL PATHOLOGY AND PATHOPHYSIOLOGY
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Bulletin of Experimental Biology and Medicine Aims and scope

We studied the effect of ultrasonic waves with a frequency of 20-45 kHz on behavioral reactions of rats after 7, 14 and 21 days of continuous exposure. A decrease in the number of social contacts in the social interest test was recorded in all groups, while lengthening of immobility time in Porsolt test was found only in the groups exposed to ultrasound for 2 and 3 weeks. Memory impairment in the new object recognition test was recorded only after 21 days of stressing. Chronic exposure to ultrasound of variable frequencies leads to the development of a depressive-like state in rats and the duration of exposure affects the specificity of the observed disorders. Different protocols of using of this model help to determine the stages of depressive-like condition in rats that can serve as a basis for the development of new methods of depressive disorders treatment.

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Authors and Affiliations

  1. M. V. Lomonosov Moscow State University, Moscow, Russia

    A. V. Gorlova, D. A. Pavlov & V. M. Ushakova

  2. V. P. Serbsky Federal Medical Research Centre of Psychiatry and Narcology of the Ministry of Health of the Russian Federation, Moscow, Russia

    E. A. Zubkov, A. Yu. Morozova, A. N. Inozemtsev & V. P. Chekhonin

Authors
  1. A. V. Gorlova
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  2. D. A. Pavlov
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  3. V. M. Ushakova
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  4. E. A. Zubkov
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  5. A. Yu. Morozova
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  6. A. N. Inozemtsev
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  7. V. P. Chekhonin
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Corresponding author

Correspondence to A. V. Gorlova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 163, No. 3, pp. 271-274, March, 2017

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Gorlova, A.V., Pavlov, D.A., Ushakova, V.M. et al. Dynamics of the Development of Depressive-Like State in Rats Stressed by Chronic Exposure of Ultrasound of Variable Frequency. Bull Exp Biol Med 163, 296–298 (2017). https://doi.org/10.1007/s10517-017-3788-9

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  • DOI: https://doi.org/10.1007/s10517-017-3788-9

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