We measured the concentrations of IL-6 and IL-15 in blood plasma of mice at different terms after forced swimming, taking into account exercise intensity and preliminary training. It was shown that training was an important factor affecting blood plasma level of IL both at rest and after single forced swimming: in trained animals, the concentration of both myokines increased immediately after swimming, while in untrained animals, this increase was observed only after 5 h. Changes in cytokine production against the background of training can be associated with various factors, including neuroendocrine mechanisms, stress, modification of intracellular signaling, as well as reorganization of transcriptional mechanisms in muscle fibers. The most important factor is shift in the ratio of monovalent cations (sodium and potassium) in the cytoplasm.
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Kapilevich LV, Kabachkova AV, Zakharova AN, Lalaeva GS, Kironenko TA, Dyakova EYu, Orlov SN. Secretory function of skeletal muscles: producing mechanisms and myokines physiological effects. Uspekhi Fiziol. Nauk. 2016;47(2):7-26. Russian.
Kiseleva NM, Kuz’menko LG, Nkane Nzola MM. Stress and lymphocytes. Pediatriya. 2012;91(1):137-143. Russian.
Scherbakov VI, Skosyreva GA, Ryabichenko TI. Role of myokines in regulation of a power exchange. Byull. Sib. Med. 2012;11(3):173-178. Russian.
Ahima RS, Park HK. Connecting myokines and metabolism. Endocrinol. Metab. (Seoul). 2015;30(3):235-245.
Brandt C, Pedersen BK. The role of exercise-induced myokines in muscle homeostasis and the defense against chronic diseases. J. Biomed. Biotechnol. 2010;2010. ID 520258. doi: 10.1155/2010/520258.
Iizuka K, Machida T, Hirafuji M. Skeletal muscle is an endocrine organ. J. Pharmacol. Sci. 2014;125(2):125-131.
Kapilevich LV, Kironenko TA, Zaharova AN, Kotelevtsev YV, Dulin NO, Orlov SN. Skeletal muscle as an endocrine organ: role of [Na+]i/[K+]i-mediated excitation-transcription coupling. Genes. Dis. 2015;2(4):328-336.
Nielsen AR, Pedersen BK. The biological roles of exerciseinduced cytokines: IL-6, IL-8, and IL-15. Appl. Physiol. Nutr. Metab. 2007;32(5):833-839.
Ost M, Coleman V, Kasch J, Klaus S. Regulation of myokine expression: role of exercise and cellular stress. Free Radic. Biol. Med. 2016;98:78-89.
Pedersen BK. Muscles and their myokines. J. Exp. Biol. 2011;214(Pt 2):337-346.
Pedersen BK, Akerström TC, Nielsen AR, Fischer CP. Role of myokines in exercise and metabolism. J. Appl. Physiol. (1985). 2007;103(3):1093-1098.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 163, No. 1, pp. 14-17, January, 2017
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Kapilevich, L.V., Kironenko, T.A., Zakharova, A.N. et al. Level of Interleukins IL-6 and IL-15 in Blood Plasma of Mice after Forced Swimming Test. Bull Exp Biol Med 163, 10–13 (2017). https://doi.org/10.1007/s10517-017-3725-y
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DOI: https://doi.org/10.1007/s10517-017-3725-y