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Combined Effects of M1 Muscarinic Acetylcholine Receptor Agonist TBPB and α7n-Acetylcholine Receptor Activator GTS-21 on Mouse Mortality and Blood Concentration of Proinflammatory Cytokines in Sepsis

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Experiments on random-bred albino mice showed that M1 muscarinic acetylcholine receptor agonist (TBPB) and α7n-acetylcholine receptor agonist (GTS-21) significantly reduced mortality of mice with experimental sepsis (intraperitoneally administration of E. coli) in 4 and 24 h after modeling by reducing blood concentration of proinflammatory cytokines TNF-α, IL-1β, and IL-6. Combined treatment with TBPB and GTS-21 determined their additive effect.

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References

  1. Zabrodskii PF. Effect of armin on factors of nonspecific organism’s resistance and primary humoral response. Farmakol. Toksikol. 1987;49(2):57-60. Russian.

    Google Scholar 

  2. Zabrodskii PF. Variation in antiinfectious nonspecific resistance of the organism caused by cholinergic stimulation. Bull. Exp. Biol. Med. 1995;120(2):809-811.

    Article  Google Scholar 

  3. Zabrodskii PF. Immunotoxicology of Organophosphorus Compounds. Saratov, 2016. Russian.

  4. Bonaz BL, Bernstein CN. Brain-gut interactions in inflammatory bowel disease. Gastroenterology. 2013;144(1):36-49.

    Article  PubMed  Google Scholar 

  5. Eftekhari G, Hajiasgharzadeh K, Ahmadi-Soleimani SM, Dehpour AR, Semnanian S, Mani AR. Activation of central muscarinic receptor type 1 prevents development of endotoxin tolerance in rat liver. Eur. J. Pharmacol. 2014;740:436-441.

    Article  CAS  PubMed  Google Scholar 

  6. Egea J, Buendia I, Parada E, Navarro E, León R, Lopez MG. Anti-inflammatory role of microglial alpha7 nAChRs and its role in neuroprotection. Biochem. Pharmacol. 2015;97(4):463-472.

    Article  CAS  PubMed  Google Scholar 

  7. Jones CK, Brady AE, Davis AA, Xiang Z, Bubser M, Tantawy MN, Kane AS, Bridges TM, Kennedy JP, Bradley SR, Peterson TE, Ansari MS, Baldwin RM, Kessler RM, Deutch AY, Lah JJ, Levey AI, Lindsley CW, Conn PJ. Novel selective allosteric activator of the M1 muscarinic acetylcholine receptor regulates amyloid processing and produces antipsychotic-like activity in rats. J. Neurosci. 2008;28(41):10,422-10,433.

    Article  CAS  Google Scholar 

  8. Kox M, Pickkers P. Modulation of the innate immune response through the vagus nerve. Nephron. 2015;131(2):79-84.

    Article  CAS  PubMed  Google Scholar 

  9. Martelli D, McKinley MJ, McAllen RM. The cholinergic anti-inflammatory pathway: a critical review. Auton. Neurosci. 2014;182:65-69.

    Article  CAS  PubMed  Google Scholar 

  10. Martin GS. Sepsis, severe sepsis and septic shock: changes in incidence, pathogens and outcomes. Expert Rev. Anti Infect. Ther. 2012;10(6):701-706.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Norman GJ, Morris JS, Karelina K, Weil ZM, Zhang N, Al-Abed Y, Brothers HM, Wenk GL, Pavlov VA, Tracey KJ, Devries AC. Cardiopulmonary arrest and resuscitation disrupts cholinergic anti-inflammatory processes: a role for cholinergic α7 nicotinic receptors. J. Neurosci. 2011;31(9):3446-3452.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Pavlov VA, Wang H, Czura CJ, Friedman SG, Tracey KJ. The cholinergic anti-inflammatory pathway: a missing link in neuroimmunomodulation. Mol. Med. 2003;9(5-8):125-134.

    CAS  PubMed  PubMed Central  Google Scholar 

  13. Payolla TB, Lemes SF, de Fante T, Reginato A, Mendes da Silva C, de Oliveira Micheletti T, Rodrigues HG, Torsoni AS, Milanski M, Torsoni MA. High-fat diet during pregnancy and lactation impairs the cholinergic anti-inflammatory pathway in the liver and white adipose tissue of mouse offspring. Mol. Cell. Endocrinol. 2016;422:192-202.

    Article  CAS  PubMed  Google Scholar 

  14. Pruett SB, Fan R, Cheng B, Glover M, Tan W, Deng X. Innate immunity and inflammation in sepsis: mechanisms of suppressed host resistance in mice treated with ethanol in a binge-drinking model. Toxicol. Sci. 2010;117(2):314-324.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Song DJ, Huang XY, Ren LC, Yang XH, Xiao MZ, Wang S. Effect of lentiviral vector encoding on triggering receptor expressed on myeloid cells 1 on expression of inflammatory cytokine in septic mice infected by Bacteroides fragilis. Zhonghua Shao Shang Za Zhi. 2009;25(1):36-41.

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Saratov Branch of Samara Medical Institute REAVIZ, Saratov, Russia

    P. F. Zabrodskii, M. S. Gromov & V. V. Maslyakov

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  1. P. F. Zabrodskii
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  2. M. S. Gromov
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  3. V. V. Maslyakov
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Correspondence to P. F. Zabrodskii.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 162, No. 12, pp. 718-721, December, 2016

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Zabrodskii, P.F., Gromov, M.S. & Maslyakov, V.V. Combined Effects of M1 Muscarinic Acetylcholine Receptor Agonist TBPB and α7n-Acetylcholine Receptor Activator GTS-21 on Mouse Mortality and Blood Concentration of Proinflammatory Cytokines in Sepsis. Bull Exp Biol Med 162, 750–753 (2017). https://doi.org/10.1007/s10517-017-3704-3

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  • DOI: https://doi.org/10.1007/s10517-017-3704-3

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