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Prenatal Hyperhomocysteinemia Impairs Hypothalamic Regulation of Reproductive Cycles in Rat Progeny

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Effects of prenatal hyperhomocysteinemia on hypothalamic regulation of estrous cycles were studied in female rats. In mature rats exposed to prenatal hyperhomocysteinemia, changes in the catecholamine content in hypothalamic areas responsible for the formation of the preovulatory surge of gonadotropin-releasing hormone were revealed: the level of norepinephrine in the medial preoptic area decreased and concentration of dopamine in the median eminence with arcuate nuclei increased. Administration of melatonin attenuated the observed changes, which can be related to neuroprotective effects of this hormone determined by its antioxidant properties.

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Authors and Affiliations

  1. D. O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, St. Petersburg, Russia

    A. V. Arutyunyan, I. V. Zaloznyaya, G. O. Kerkeshko, Yu. P. Milyutina & A. V. Korenevskii

Authors
  1. A. V. Arutyunyan
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  2. I. V. Zaloznyaya
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  3. G. O. Kerkeshko
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  4. Yu. P. Milyutina
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  5. A. V. Korenevskii
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Corresponding author

Correspondence to A. V. Arutyunyan.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 162, No. 12, pp. 704-707, December, 2016

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Arutyunyan, A.V., Zaloznyaya, I.V., Kerkeshko, G.O. et al. Prenatal Hyperhomocysteinemia Impairs Hypothalamic Regulation of Reproductive Cycles in Rat Progeny. Bull Exp Biol Med 162, 738–740 (2017). https://doi.org/10.1007/s10517-017-3701-6

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  • DOI: https://doi.org/10.1007/s10517-017-3701-6

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