Skip to main content

Advertisement

SpringerLink
Log in

Albumin in the Vitreous Body, Retina and Lens of Human Fetal Eye

  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

The content of serum albumin was evaluated in the vitreous body, retina, and lens of human fetuses of 14, 16, 17, 18 and 24 weeks of gestation. Albumin was detected in these tissues. PCR analysis revealed no albumin mRNA in the retina or in the lens, while in fetal liver (control) mRNA for this protein was expressed. These findings suggest that serum albumin is not synthesized by cells of retina and lens, but is captured by them. The presence of serum albumin in human eye tissues suggests its involvement in the metabolism, maintenance of tissue volume, and antioxidant reactions.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Panova IG, Tatikolov AS, Sukhikh GT. Correlation between the content of albumin and carotenoids in human vitreous body during prenatal development. Bull. Exp. Biol. Med. 2007;144(5):681-683.

    Article  CAS  PubMed  Google Scholar 

  2. Tatikolov AS, Panova IG, Ishchenko AA, Kudinova MA. Spectral and fluorescent study of the interaction of squarylium dyes, derivatives of 3H-indolium, with albumins. Biophysics. 2010;55(1):35-40.

    Article  Google Scholar 

  3. Fanali G, di Masi A, Trezza V, Marino M, Fasano M, Ascenzi P. Human serum albumin: From bench to bedside. Mol. Aspects Med. 2012;33(3):209-290.

    Article  CAS  PubMed  Google Scholar 

  4. Hankins J. The role of albumin in fluid and electrolyte balance. J. Infus. Nurs. 2006;29(5):260-265.

    Article  PubMed  Google Scholar 

  5. Jauniaux E, Gulbis B, Jurkovic D, Campbell S, Collins WP, Ooms HA. Relationship between protein concentrations in embryological fluids and maternal serum and yolk sac size during human early pregnancy. Hum. Reprod. 1994;9(1):161-166.

    Article  CAS  PubMed  Google Scholar 

  6. Naval J, Calvo M, Laborda J, Dubouch P, Frain M, Sala-Trepat JM, Uriel J. Expression of mRNAs for alpha-fetoprotein (AFP) and albumin and incorporation of AFP and docosahexaenoic acid in baboon fetuses. J. Biochem. 1992;111(5):649-654.

    Article  CAS  PubMed  Google Scholar 

  7. Panova IG, Tatikolov AS, Stroeva OG. Albumins and carotenoids of the human fetal vitreous body and their morphogenetic role during midgestation. J. J. Ophthalmol. 2015;1(2):013.

    Google Scholar 

  8. Peters T Jr. All about Albumin: Biochemistry, Genetics, and Medical Application. San Diego, 1996.

  9. Prajapati KD, Sharma SS, Roy N. Current perspectives on potential role of albumin in neuroprotection. Rev. Neurosci. 2011;22(3):355-363.

    CAS  PubMed  Google Scholar 

  10. Sabah J, McConkey E, Welti R, Albin K, Takemoto LJ. Role of albumin as a fatty acid carrier for biosynthesis of lens lipids. Exp. Eye Res. 2005;80(1):31-36.

    Article  CAS  PubMed  Google Scholar 

  11. Taverna M, Marie AL, Mira JP, Guidet B. Specific antioxidant properties of human serum albumin. Ann. Intensive Care. 2013;3(1):4. doi: 10.1186/2110-5820-3-4.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Yang J, Klassen H, Pries M, Wang W, Nissen MH. Vitreous humor and albumin augment the proliferation of cultured retinal precursor cells. J. Neurosci. Res. 2009;87(2):495-502.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. N. K. Koltsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia

    I. G. Panova & Yu. A. Smirnova

  2. N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia

    A. S. Tatikolov

  3. V. I. Kulakov Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russian Federation, Moscow, Russia

    R. A. Poltavtseva & G. T. Sukhikh

Authors
  1. I. G. Panova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. S. Tatikolov
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yu. A. Smirnova
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. R. A. Poltavtseva
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. G. T. Sukhikh
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to I. G. Panova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 162, No. 11, pp. 578-580, November, 2016

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Panova, I.G., Tatikolov, A.S., Smirnova, Y.A. et al. Albumin in the Vitreous Body, Retina and Lens of Human Fetal Eye. Bull Exp Biol Med 162, 629–631 (2017). https://doi.org/10.1007/s10517-017-3673-6

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-017-3673-6

Key Words

Search

Navigation