Bulletin of Experimental Biology and Medicine

, Volume 162, Issue 4, pp 462–465 | Cite as

Effect of Sulfation and Molecular Weight on Anticoagulant Activity of Dextran

  • N. N. DrozdEmail author
  • Yu. S. Logvinova
  • M. A. Torlopov
  • E. V. Udoratina

Sulfation (to 2.8) of dextrans with molecular weight of 150 and 20 kDa was followed by the appearance of anticoagulant activity that increased with decreasing their molecular weight and did not depend on antithrombin, plasma inhibitor of serine proteases of the blood coagulation system. Antithrombin activity of dextran sulfate with a molecular weight of 20 kDa reached 12.6-15.3 U/mg. Dextran sulfates with molecular weights of 20 and 150 kDa did not potentiate ADP-induced human platelet aggregation.

Key Words

dextran dextran sulfate anticoagulant activity 


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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • N. N. Drozd
    • 1
    Email author
  • Yu. S. Logvinova
    • 1
  • M. A. Torlopov
    • 2
  • E. V. Udoratina
    • 2
  1. 1.National Research Center for Hematology, Ministry of Health of the Russian FederationMoscowRussia
  2. 2.Institute of Chemistry, Komi Science CenterUral Division of the Russian Academy of SciencesSyktyvkarRussia

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