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Effects of Anti-CD206 Antibodies on Macrophage Functions in Male CBF1 Mice with Lipidemia

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The effects of anti-CD208 antibodies (mannose receptor) on functional characteristics of peritoneal macrophages were studied in intact mice and mice with lipidemia induced by poloxamer-407. Lipidemia was associated with suppression of phagocytosis and increase in spontaneous proliferative potential and NO production by macrophages. Anti-CD206 antibodies suppressed NO production by macrophages in mice with lipidemia.

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References

  1. Bolotova EV, Samorodskaya IV, Komissarova IM. Relationship of body mass index and abdominal obesity in rural population of Krasnodarsky kray taken. Ozhirenie Metabolizm. 2016;13(1):25-31. Russian.

  2. Didkovskii NA, Malashenkova IK, Tanasova AN, Zuikov IA, Zuikova IN, Khitrik NM, Sarsaniya ZhSh. Pathogenetic aspects of severe course of herpetic infection. Bull. Exp. Biol. Med. 2007;144(3):447-451.

    Article  CAS  PubMed  Google Scholar 

  3. Kondrashova NM, Plekhova NG, Zavorueva DV, Somova LM, Geltser BI, Kostyushko AV. Cellular factors of local protection under community acquired pneumonia. Tsitologiya. 2010;52(7):588-596. Russian.

  4. Ampel NM, Nelson DK, Li L, Dionne SO, Lake DF, Simmons KA, Pappagianis D. The mannose receptor mediates the cellular immune response in human coccidioidomycosis. Infect. Immun. 2005;73(4):2554-2555.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Chandak PG, Radovic B, Aflaki E, Kolb D, Buchebner M, Fröhlich E, Magnes C, Sinner F, Haemmerle G, Zechner R, Tabas I, Levak-Frank S, Kratky D. Efficient phagocytosis requires triacylglycerol hydrolysis by adipose triglyceride lipase. J. Biol. Chem. 2010;285(26):20 192-20 201.

  6. Guasconi L, Serradell MC, Garro AP, Iacobelli L, Masih DT. C-type lectins on macrophages participate in the immunomodulatory response to Fasciola hepatica products. Immunology. 2011;133(3):386-396.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Hellmann J, Zhang MJ, Tang Y, Rane M, Bhatnagar A, Spite M. Increased saturated fatty acids in obesity alter resolution of inflammation in part by stimulating prostaglandin production. J. Immunol. 2013;191(3):1383-1392.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Korolenko TA, Johnston TP, Dubrovina NI, Kisarova YA, Zhanaeva SY, Cherkanova MS, Filjushina EE, Alexeenko TV, Machova E, Zhukova NA. Effect of poloxamer 407 administration on the serum lipids profile, anxiety level and protease activity in the heart and liver of mice. Interdiscip. Toxicol. 2013;6(1):18-25.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Korolenko T., Tuzikov FV, Johnston TP, Tuzikova NA, Kisarova YA, Zhanaeva SY, Alexeenko TV, Zhukova NA, Brak IV, Spiridonov VK, Filjushina EE, Cherkanova MS, Monoszon AA. The influence of repeated administration of poloxamer 407 on serum lipoproteins and protease activity in mouse liver and heart. Can. J. Physiol. Pharmacol. 2012;90(11):1456-1468.

    Article  CAS  PubMed  Google Scholar 

  10. Moseman AP, Moseman EA, Schworer S, Smirnova I, Volkova T, von Andrian U, Poltorak A. Mannose receptor 1 mediates cellular uptake and endosomal delivery of CpG-motif containing oligodeoxynucleotides. J. Immunol. 2013;191(11):5615-5624.

    Article  CAS  PubMed  Google Scholar 

  11. Pisareva EE, Goncharova IA, Tuzikov FV, Goncharova NV, Makhova E, Korolenko TA. Role of changes in serum chitotriosidase activity in mice under conditions of hyperlipidemia and lipid-lowering effect of carboxymethylated (1-3)-β-Dglycan. Bull. Exp. Biol. Med. 2014;157(5):555-559.

    Article  CAS  PubMed  Google Scholar 

  12. Shimada K, Takimoto H, Yano I, Kumazawa Y. Involvement of mannose receptor in glycopeptidolipid-mediated inhibition of phagosome-lysosome fusion. Microbiol. Immunol. 2006;50(3):243-51.

    Article  CAS  PubMed  Google Scholar 

  13. Zizzo G, Hilliard BA, Monestier M, Cohen PL. Efficient clearance of early apoptotic cells by human macrophages requires M2c polarization and MerTK induction. J. Immunol. 2012;189(7):3508-3520.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia

    A. P. Lykov, O. V. Poveshchenko, N. A. Bondarenko & M. A. Surovtseva

  2. Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia

    T. A. Korolenko & N. V. Goncharova

  3. Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia

    L. V. Sakhno

Authors
  1. A. P. Lykov
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  2. T. A. Korolenko
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  3. L. V. Sakhno
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  4. O. V. Poveshchenko
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  5. N. A. Bondarenko
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  6. M. A. Surovtseva
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  7. N. V. Goncharova
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Corresponding author

Correspondence to A. P. Lykov.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 162, No. 8, pp. 202-205, August, 2016

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Lykov, A.P., Korolenko, T.A., Sakhno, L.V. et al. Effects of Anti-CD206 Antibodies on Macrophage Functions in Male CBF1 Mice with Lipidemia. Bull Exp Biol Med 162, 237–239 (2016). https://doi.org/10.1007/s10517-016-3584-y

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  • DOI: https://doi.org/10.1007/s10517-016-3584-y

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