Iron-chelating activity of synthesized spirocyclic hydroxamic acids, their toxicity, and effects on mitochondrial function were studied using primary culture of cerebral cortical neurons from newborn rats. All tested compounds effectively chelated Fe(II) ions. Activity of spirocyclic hydroxamic acids more strictly depended on the structure their piperidine, but not imidazolidine fragment. All compounds were non-toxic for normal neuronal culture.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Vystorop IV, Konovalova NP, Chernyak AV, Sashenkova TE, Klimanova EN, Utienyshev AN, Fedorov BS, Shilov GV, Nelyubina YuV, Kostyanovsky RG. Cyclic hydroxamic acids derived from α-amino acids 2. Regioselective synthesis, crystal structure, and antitumor activity of spiropiperidine- imidazolidine hydroxamic acids based on glycine and dl-alanine. Rus. Chem. Bull. 2013;62(5):1272-1281.
Konovalova NP, Vystorop IV, Sashenkova TE, Klimanova EN, Mishchenko DV, Allayarova UYu, Goncharova SA, Raevskaya TA, Yakushchenko TN, Chernyak AV. Cyclic hydroxamic acids as chemosensibilizators of cytostatic therapy. Vopr. Onkol. 2013;59(5):620-622. Russian.
Neganova ME, Serkova TP, Klochkov SG, Afanas’eva SV, Shevtsova EF, Bachurin SO. Neuroprotective properties of allomargaritarina, a new tryptamine derivative of the natural alkaloid securinine. Estesstv. Tekh. Nauki. 2011;(5):86-90. Russian.
Tat’yanenko LV, Konovalova NP, Dobrokhotova OV, Pikhteleva IYu, Mishchenko DV, Fedorov BS, Vystorop IV. Effect of cyclic hydroxamic acids derived from glycine and D,L-alanine on activity of Ca2+ Mg2+-ATPase hydrolases of sarcoplasmic reticulum and cyclic guanosine monophosphate phosphodiesterase. Pharmaceutical Chemistry Journal. 2013;47(5):235-238.
Akerman KE, Wikström MK. Safranine as a probe of the mitochondrial membrane potential. FEBS Lett. 1976;68(2):191-197.
Bachurin SO, Shevtsova EP, Kireeva EG, Oxenkrug GF, Sablin SO. Mitochondria as a target for neurotoxins and neuroprotective agents. Ann. N.Y. Acad. Sci. 203;993:334-344.
Gülçin I. Comparison of in vitro antioxidant and antiradical activities of L-tyrosine and L-Dopa. Amino Acids. 2007;32(3):431-438.
Khan A, Wood P, Moskal J. Hydroxamic acid derivatives, preparation and therapeutic uses thereof. WO 2010065709 A2, 10.06.2010.
Mosmann J. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods. 1983;65(1-2):55-63.
Neganova ME, Klochkov SG, Afanasieva SV, Serkova TP, Chudinova ES, Bachurin SO, Reddy VP, Aliev G, Shevtsova EF. Neuroprotective effects of the securinine-analogues: identification of allomargaritarine as a lead compound. CNS Neurol. Disord. Drug Targets. 2016;15(1):102-107.
Pontiki E, Hadjipavlou-Litina D. Histone deacetylase inhibitors (HDACIs). Structure—activity relationships: history and new QSAR perspectives. Med. Res. Rev. 2012;32(1):1-165.
Suh DH, Kim MK, Kim HS, Chung HH, Song YS. Epigenetic therapies as a promising strategy for overcoming chemoresistance in epithelial ovarian cancer. J. Cancer Prev. 2013;18(3):227-234.
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 161, No. 8, pp. 192-194, August, 2016.
Rights and permissions
About this article
Cite this article
Neganova, M.E., Mishchenko, D.V., Serkova, T.P. et al. Biological Activity of Spirocyclic Hydroxamic Acids. Bull Exp Biol Med 162, 228–230 (2016). https://doi.org/10.1007/s10517-016-3582-0
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-016-3582-0