Increased frequency of cells with chromosomal aberrations was revealed in 48-h cultures of peripheral blood lymphocytes isolated North Ossetia residents with impaired reproductive function. After 2-week treatment with antimutagenic drug Afobazole, the percentage of cells with chromosomal aberrations significantly decreased from 3.77±0.20 to 2.48±0.24% (p<0.001). Significant differences between chromosome damage levels before and after administration of the drug suggest that Afobazole could be recommended for protective purposes to this group of patients.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 161, No. 8, pp. 188-191, August, 2016
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Chshieva, F.T. Antimutagenic Effect of Afobazole on Blood Leukocytes in Individuals with Reproductive Dysfunction under Conditions of Anthropogenic Load. Bull Exp Biol Med 162, 225–227 (2016). https://doi.org/10.1007/s10517-016-3581-1
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DOI: https://doi.org/10.1007/s10517-016-3581-1