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Selective Blockade of α2-Adrenoceptor Subtypes Modulates Contractility of Rat Myocardium

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Bulletin of Experimental Biology and Medicine Aims and scope

The study examined the dose-dependent effects of selective antagonists of α2A/D-, α2B-, and α2C- adrenoceptors applied in concentrations of 10—9-10—5 M on atrial and ventricular contractility of rat myocardium in vitro. Selective blockade of each α2-adrenoceptor subtype affected the contractile force of the atrial and ventricular strips. Various concentrations of α2A/D- and α2C-adrenoceptor antagonists produced positive inotropic effect on ventricular strips and negative effect on atrial strips. α2B-Adrenoceptor blocker in the majority of the tested concentrations produced a positive inotropic effect in both atria and ventricles.

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References

  1. Zefirov TL, Ziatdinova NI, Khisamieva LI, Zefirov AL. Comparative analysis of the impact of α1-and α2-adrenoreceptor blockade on cardiac function in rats during postnatal ontogeny. Bull. Exp. Biol. Med. 2011;151(6):664-666.

    Article  CAS  PubMed  Google Scholar 

  2. Zefirov TL, Khisamieva LI, Ziyatdinova NI, Zefirov AL. Effect of selective blockade of α2-adrenoceptor subtypes on cardiovascular system in rats. Bull. Exp. Biol. Med. 2015;158(4): 410-412.

    Article  CAS  PubMed  Google Scholar 

  3. Brede M, Nagy G, Philipp M, Sorensen JB, Lohse MJ, Hein L. Differential control of adrenal and sympathetic catecholamine release by alpha 2-adrenoceptor subtypes. Mol. Endocrinol. 2003;17(8):1640-1646.

    Article  CAS  PubMed  Google Scholar 

  4. Brede M, Wiesmann F, Jahns R, Hadamek K, Arnolt C, Neubauer S, Lohse MJ, Hein L. Feedback inhibition of catecholamine release by two different alpha2-adrenoceptor subtypes prevents progression of heart failure. Circulation. 2002;106(19):2491-2496.

    Article  CAS  PubMed  Google Scholar 

  5. Brodde OE, Leineweber K. Autonomic receptor systems in the failing and aging human heart: similarities and differences. Eur. J. Pharmacol. 2004;500(1-3):167-176.

    Article  CAS  PubMed  Google Scholar 

  6. Civantos Calzada B, Aleixandre de Artiñano A. Alpha-adrenoceptor subtypes. Pharmacol. Res. 2001;44(3):195-208.

    Article  CAS  PubMed  Google Scholar 

  7. El-Ayoubi R, Menaouar A, Gutkowska J, Mukaddam-Daher S. Imidazoline receptors but not alpha 2-adrenoceptors are regulated in spontaneously hypertensive rat heart by chronic moxonidine treatment. J. Pharmacol. Exp. Ther. 2004;310(2):446-451.

    Article  CAS  PubMed  Google Scholar 

  8. Gyires K, Zádori ZS, Török T, Mátyus P. alpha(2)-Adrenoceptor subtypes-mediated physiological, pharmacological actions. Neurochem. Int. 2009;55(7):447-453.

    Article  CAS  PubMed  Google Scholar 

  9. Leineweber K. Beta-adrenergic receptor polymorphism in human cardiovascular disease. Ann. Med. 2004;36(Suppl. 1):64-69.

    Article  CAS  PubMed  Google Scholar 

  10. Lymperopoulos A, Rengo G, Koch WJ. Adrenal adrenoceptors in heart failure: fine-tuning cardiac stimulation. Trends Mol. Med. 2007;13(12):503-511.

    Article  CAS  PubMed  Google Scholar 

  11. Maltsev AV, Kokoz YM, Evdokimovskii EV, Pimenov OY, Reyes S, Alekseev AE. Alpha-2 adrenoceptors and imidazoline receptors in cardiomyocytes mediate counterbalancing effect of agmatine on NO synthesis and intracellular calcium handling. J. Mol. Cell. Cardiol. 2014;68:66-74.

    Article  CAS  PubMed  Google Scholar 

  12. Philipp M, Brede M, Hein L. Physiological significance of alpha(2)-adrenergic receptor subtype diversity: onereceptor is not enough. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2002;283(2):R287-R295.

    Article  CAS  PubMed  Google Scholar 

  13. Zefirov TL, Khisamieva LI, Ziyatdinova NI, Zefirov AL. Peculiar effects of selective blockade of a2-adrenoceptor subtypes on cardiac chronotropy in newborn rats. Bull. Exp. Biol. Med. 2015;160(1):6-8.

    Article  CAS  PubMed  Google Scholar 

  14. Zefirov TL, Ziyatdinova NI, Khisamieva LI, Zefirov AL. Effect of a2-adrenoceptor stimulation on cardiac activity in rats. Bull. Exp. Biol. Med. 2014;157(2):194-197.

    Article  CAS  PubMed  Google Scholar 

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Correspondence to T. L. Zefirov.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 162, No. 8, pp. 136-139, August 2016

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Zefirov, T.L., Khisamieva, L.I., Ziyatdinova, N.I. et al. Selective Blockade of α2-Adrenoceptor Subtypes Modulates Contractility of Rat Myocardium. Bull Exp Biol Med 162, 177–179 (2016). https://doi.org/10.1007/s10517-016-3569-x

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  • DOI: https://doi.org/10.1007/s10517-016-3569-x

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