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Selank Inhibits Ethanol-Induced Hyperlocomotion and Manifestation of Behavioral Sensitization in DBA/2 Mice

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The effect of non-benzodiazepine anxiolytics on the ethanol-induced hyperlocomotion and behavioral sensitization was assessed in male DBA/2 mice. Selank that enhances activity of the endogenous opioid system (0.3 mg/kg, intraperitoneally), similar to the nonselective opiate receptor blocker naloxone (1.0 mg/kg, intraperitoneally), prevented the development of ethanol-induced (2.0 g/kg intraperitoneally) hyperlocomotion, in contrast to σ1-receptors agonist Afobazole (1.0 mg/kg, intraperitoneally) that did not inhibit ethanol-induced behavioral stimulation. Single dose of Selank significantly blocked manifestation of motor sensitization without affecting its formation. These findings suggest that Selank can modulate the motivational effects of ethanol.

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Authors and Affiliations

  1. V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia

    L. G. Kolik, A. V. Nadorova & S. B. Seredenin

Authors
  1. L. G. Kolik
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  2. A. V. Nadorova
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  3. S. B. Seredenin
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Correspondence to L. G. Kolik.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 161, No. 7, pp. 67-71, July, 2016

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Kolik, L.G., Nadorova, A.V. & Seredenin, S.B. Selank Inhibits Ethanol-Induced Hyperlocomotion and Manifestation of Behavioral Sensitization in DBA/2 Mice. Bull Exp Biol Med 162, 56–59 (2016). https://doi.org/10.1007/s10517-016-3544-6

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  • DOI: https://doi.org/10.1007/s10517-016-3544-6

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