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CB-Receptor Agonist HU-210 Mimics the Postconditioning Phenomenon of Isolated Heart

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Bulletin of Experimental Biology and Medicine Aims and scope

CB receptor agonist HU-210 exhibits an infarction-limiting effect during in vitro reperfusion of the heart after focal ischemia. This effect is paralleled by a decrease in left-ventricular developed pressure and double product. In addition, HU-210 reduces end-diastolic pressure during the reperfusion period, which indirectly attests to reduced Ca2+ overload of cardiomyocytes.

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References

  1. Lishmanov YuB, Maslov LN, Lasukova OV. Role of cAMP, cGMP, NO[synthase, KATP-channels and protein kinase c in development of cardioprotective effect of cannabinoid receptor agonist HU-210. Sib. Med. h. (Tomsk). 2012;27(2):115-119. Russian.

    Google Scholar 

  2. Maslov LN, Lasukova OV, Krylatov AV, Hanuš L, Lishmanov YuB. Mediated role of NO-syntase, protein kinase C and K ATP-channels in realization of cardioprotective impact of cannabinoid HU-210. Eksp. Biol. Farmakol. 2012;75(12):15-18. Russian.

    CAS  Google Scholar 

  3. Maslov LN, Mrochek AG, Schepetkin IA, Headrick JP, Hanus L, Barzakh EI, Lishmanov AYu, Gorbunov AS, Tsybulnikov SYu, Baykov AN. Protein kinases role in adaptive phenomenon of heart ischemic postconditioning development. Ross. Fiziol. Zh. 2013;99(4):433-452. Russian.

    CAS  Google Scholar 

  4. Menzorov MV, Shutov AM, Serov VA, Saenko YV, Grishenkin IY. Type of thrombolytic agent and rate of acute kidney injury in patients with myocardial infarction. Kardiologiya. 2015;55(2):16-20. Russian.

    Article  CAS  PubMed  Google Scholar 

  5. Vishnevskii AG, ed. The population of Russia in 2012. Twentieth annual demographic report. Moscow, 2014. Russian.

  6. Tarasov RS, Ganyukov VL, Shushpannikov PA, Barbarash OL, Barbarash LS. Optimal timing of the second stage of revascularization in the treatment of patients with ST-elevation myocardial infarction and multivascular involvement. Kardiologiya. 2013;53(7):9-12. Russian.

    CAS  PubMed  Google Scholar 

  7. Blatt A, Elbaz-Greener G.A, Mizrachi A, J’bara Z, Taraboulos T, Litovchik I, Vered Z, Minha S. Adjunctive mild hypothermia therapy to primary percutaneous coronary intervention in patients with ST segment elevation myocardial infarction complicated with cardiogenic shock: A pilot feasibility study. Cardiol. J. 2015;22(3):285-289.

    Article  PubMed  Google Scholar 

  8. Fryer RM, Hsu AK, Eells JT, Nagase H, Gross GJ. Opioidinduced second window of cardioprotection: potential role of mitochondrial KATP channels. Circ. Res. 1999;84(7):846-851.

    Article  CAS  PubMed  Google Scholar 

  9. Lasukova OV, Maslov LN, Ermakov SYu, Krylatov AV, Crawford D, Barth F, Hanus LO. Role of cannabinoid receptors in regulation of cardiac tolerance to ischemia and reperfusion. Biol. Bull. 2008;35(4):404-410.

    Article  CAS  Google Scholar 

  10. Neckár J, Sźárszoi O, Herget J, Ostádal B, Kolár F. Cardioprotective effect of chronic hypoxia is blunted by concomitant hypercapnia. Physiol. Res. 2003;52(2):171-175.

    PubMed  Google Scholar 

  11. Ostadal B, Kolar F. Cardiac Ischemia: From Injury to Protection. Boston; Dordrecht; London, 1999.

  12. Pertwee RG. Pharmacology of cannabinoid receptor ligands. Curr. Med. Chem. 1999;6(8):635-664.

    CAS  PubMed  Google Scholar 

  13. Shavadia J, Zheng Y, Dianati Maleki N, Huber K, Halvorsen S, Goldstein P, Gershlick AH, Wilcox R, Van de Werf F, Armstrong PW. Infarct Size, Shock, and Heart Failure: Does Reperfusion Strategy Matter in Early Presenting Patients With ST-Segment Elevation Myocardial Infarction? J. Am. Heart Assoc. 2015;4(8):e002049.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Yellon DM, Downey JM. Preconditioning the myocardium: from cellular physiology to clinical cardiology. Physiol. Rev. 2003;83(4):1113-1151.

    Article  CAS  PubMed  Google Scholar 

  15. Zhao ZQ, Corvera JS, Halkos ME, Kerendi F, Wang NP, Guyton RA, Vinten-Johansen J. Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning. Am. J. Physiol. Heart Circ. Physiol. 2003;285(2):H579-H588.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Research Institute for Cardiology, Tomsk, Russia

    A. S. Gorbunov, L. N. Maslov, S. Yu. Tsibulnikov, I. G. Khaliulin, A. V. Tsepokina, M. V. Khutornaya & A. G. Kutikhin

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  1. A. S. Gorbunov
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  2. L. N. Maslov
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  3. S. Yu. Tsibulnikov
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  4. I. G. Khaliulin
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  5. A. V. Tsepokina
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  6. M. V. Khutornaya
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  7. A. G. Kutikhin
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Corresponding author

Correspondence to L. N. Maslov.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 162, No. 7, pp. 33-36, July, 2016

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Gorbunov, A.S., Maslov, L.N., Tsibulnikov, S.Y. et al. CB-Receptor Agonist HU-210 Mimics the Postconditioning Phenomenon of Isolated Heart. Bull Exp Biol Med 162, 27–29 (2016). https://doi.org/10.1007/s10517-016-3536-6

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  • DOI: https://doi.org/10.1007/s10517-016-3536-6

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