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Effects of Melatonin on Differentiation Potential of Ito Cells in Mice with Induced Fibrosis of the Liver

  • MORPHOLOGY AND PATHOMORPHOLOGY
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Bulletin of Experimental Biology and Medicine Aims and scope

We studied the effects of melatonin on differentiation potential of Ito cells during atypical regeneration of mouse liver under conditions of CCl4-induced fibrosis. The dynamics of fibrosis was traced at the histological level and the effects of melatonin on the differentiation potential of mouse Ito cells were evaluated. Melatonin alleviated fibrotic changes in the liver tissue and reduced differentiation of Ito cells into myofibroblasts under conditions of atypical regeneration of the liver in induced fibrosis. The hepatoprotective role of melatonin was shown.

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Authors and Affiliations

  1. M. V. Lomonosov Moscow State University, Moscow, Russia

    D. S. Nalobin, E. A. Suprunenko & V. A. Golichenkov

Authors
  1. D. S. Nalobin
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  2. E. A. Suprunenko
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  3. V. A. Golichenkov
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Correspondence to D. S. Nalobin.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 161, No. 6, pp. 807-811, June, 2016

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Nalobin, D.S., Suprunenko, E.A. & Golichenkov, V.A. Effects of Melatonin on Differentiation Potential of Ito Cells in Mice with Induced Fibrosis of the Liver. Bull Exp Biol Med 161, 845–849 (2016). https://doi.org/10.1007/s10517-016-3526-8

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  • DOI: https://doi.org/10.1007/s10517-016-3526-8

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