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Role of α7-Nicotinic Acetylcholine Receptors of B Cells in the Immunotoxic Effect of Organophosphorus Compounds

  • PHARMACOLOGY AND TOXICOLOGY
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Bulletin of Experimental Biology and Medicine Aims and scope

Experiments on white non-inbred rats demonstrated that treatment with organophosphorus compound dimethyl dichlorovinyl phosphate (DDVP) decreased T cell-independent antibody production by B cells and blood levels of IL-10 and IL-12; a similar effect was produced by GTS-21, a selective agonist of α7-nicotinic acetylcholine receptor. N-nicotinic receptor antagonist chlorisondamine in combination with DDVP partially prevented suppression of antibody production in comparison with the effect observed during intoxication with DDVP.

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References

  1. Zabrodskii PF, Grishin VA, Borodavko VK. Mechanism of suppression of phagocytic and metabolic activity of neutrophils and production of proinflammatory cytokines during chronic poisoning with organophosphorus compounds. Bull. Exp. Biol. Med. 2013;155(4):464-466.

    Article  CAS  PubMed  Google Scholar 

  2. Zabrodskii PF, Lim VG, Shekhter MS, Kuzmin AV. Role of nicotinic and muscarinic cholinoreceptors in the realization of the cholinergic anti-inflammatory pathway during the early phase of sepsis. Bull. Exp. Biol. Med. 2012;153(5):700-703.

    Article  CAS  PubMed  Google Scholar 

  3. Zabrodskii PF, Mandych VG. Immunotoxicology of Xenobiotiks. Saratov, 2007. Russian.

  4. Mail D, Brostoff J, Roth D, Roitt IM. Immunology. Moscow, 2000. Russian.

  5. Chilukuri N, Duysen EG, Parikh K, diTargiani R, Doctor BP, Lockridge O, Saxena A. Adenovirus-transduced human butyrylcholinesterase in mouse blood functions as a bioscavenger of chemical warfare nerve agents. Mol. Pharmacol. 2009;76(3):612-617.

  6. Holan V, Zajicova A, Javorkova E, Trosan P, Chudickova M, Pavlikova M, Krulova M. Distinct cytokines balance the development of regulatory T cells and interleukin-10-producing regulatory B cells. Immunology. 2014;141(4):577-586.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Hulse EJ, Davies JO, Simpson AJ, Sciuto AM, Eddleston M. Respiratory complications of organophosphorus nerve agent and insecticide poisoning. Implications for respiratory and critical care. Am. J. Respir. Crit. Care Med. 2014;190(12):1342-1354.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Lasek W, Zagożdżon R, Jakobisiak M. Interleukin 12: still a promising candidate for tumor immunotherapy? Cancer Immunol. Immunother. 2014;63(5):419-435.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Norman GJ, Morris JS, Karelina K, Weil ZM, Zhang N, Al-Abed Y, Brothers HM, Wenk GL, Pavlov VA, Tracey KJ, Devries AC. Cardiopulmonary arrest and resuscitation disrupts cholinergic anti-inflammatory processes: a role for cholinergic α7 nicotinic receptors. J. Neurosci. 2011;31(9):3446-3452.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Parikh K, Duysen EG, Snow B, Jensen NS, Manne V, Lockridge O, Chilukuri N. Gene-delivered butyrylcholinesterase is prophylactic against the toxicity of chemical warfare nerve agents and organophosphorus compounds. J. Pharmacol. Exp. Ther. 2011;337(1):92-101.

    Article  CAS  PubMed  Google Scholar 

  11. Pavlov VA, Ochani M, Yang LH, Gallowitsch-Puerta M, Ochani K, Lin X, Levi J, Parrish WR, Rosas-Ballina M, Czura CJ, Larosa GJ, Miller EJ, Tracey KJ, Al-Abed Y. Selective alpha7-nicotinic acetylcholine receptor agonist GTS-21 improves survival in murine endotoxemia and severe sepsis. Crit. Care Med. 2007;35(1):1139-1144.

    Article  CAS  PubMed  Google Scholar 

  12. Peña-Philippides JC, Razani-Boroujerdi S, Singh SP, Langley RJ, Mishra NC, Henderson RF, Sopori ML. Long- and shortterm changes in the neuroimmune-endocrine parameters following inhalation exposures of F344 rats to low-dose sarin. Toxicol. Sci. 2007;97(1):181-188.

    Article  CAS  PubMed  Google Scholar 

  13. RamaRao G, Afl ey P, Acharya J, Bhattacharya BK. Efficacy of antidotes (midazolam, atropine and HI-6) on nerve agent induced molecular and neuropathological changes. BMC Neurosci. 2014;15:47. doi: 10.1186/1471-2202-15-47.

  14. Sawyer TW, Mikler J, Worek F, Reiter G, Thiermann H, Tenn C, Weatherby K, Bohnert S. The therapeutic use of localized cooling in the treatment of VX poisoning. Toxicol. Lett. 2011;204(1):52-56.

    Article  CAS  PubMed  Google Scholar 

  15. Yanagisawa N. The nerve agent sarin: history, clinical manifestations, and treatment. Brain Nerve. 2014;66(5):561-569.

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Saratov Branch of the Samara Medical Institute REAVIZ, Saratov, Russia

    P. F. Zabrodskii, V. V. Maslyakov & M. S. Gromov

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  1. P. F. Zabrodskii
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  2. V. V. Maslyakov
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  3. M. S. Gromov
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Correspondence to P. F. Zabrodskii.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 161, No. 6, pp. 733-735, June, 2016

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Zabrodskii, P.F., Maslyakov, V.V. & Gromov, M.S. Role of α7-Nicotinic Acetylcholine Receptors of B Cells in the Immunotoxic Effect of Organophosphorus Compounds. Bull Exp Biol Med 161, 779–781 (2016). https://doi.org/10.1007/s10517-016-3508-x

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  • DOI: https://doi.org/10.1007/s10517-016-3508-x

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