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Effect of Preliminary Injection of Bone Marrow Cell Total RNA on Erythropoiesis Recovery Dynamics in Rats Exposed to an Acute γ-Irradiation

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Total RNA from the bone marrow of healthy donor rats was injected to experimental rats 6 h, 2 h, or 30 min prior to a single γ-irradiation in the sublethal dose of 6 Gy. Injection total RNA 30 min prior to the exposure most effectively restored erythropoiesis in experimental animals. In 5 days, reticulocyte count in these animals 30-fold surpassed the control (injection of 0.9% NaCl). In 12 days, the content of new erythroblastic islands in the bone marrow in rats injected with the total RNA 2 h or 30 min prior to irradiation increased significantly and erythropoiesis recovery activation was observed.

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Authors and Affiliations

  1. V. N. Orekhovich Research Institute of Biomedical Chemistry, the Russian Academy of Medical Sciences, Moscow, Russia

    N. M. Gevorkyan

  2. South Ural State Medical University, Chelyabinsk, Russia

    N. V. Tishevskaya & A. A. Bolotov

Authors
  1. N. M. Gevorkyan
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  2. N. V. Tishevskaya
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  3. A. A. Bolotov
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Corresponding author

Correspondence to N. V. Tishevskaya.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 161, No. 5, pp. 670-673, May, 2016

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Gevorkyan, N.M., Tishevskaya, N.V. & Bolotov, A.A. Effect of Preliminary Injection of Bone Marrow Cell Total RNA on Erythropoiesis Recovery Dynamics in Rats Exposed to an Acute γ-Irradiation. Bull Exp Biol Med 161, 723–726 (2016). https://doi.org/10.1007/s10517-016-3494-z

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  • DOI: https://doi.org/10.1007/s10517-016-3494-z

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