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Expression of Molecular Markers of Angiogenesis, Lymphangiogenesis, and Proliferation Depending on the Stage of Skin Melanoma

Bulletin of Experimental Biology and Medicine volume 161, pages 542–546 (2016)Cite this article

The expression of molecular markers characterizing activity of the tumor process and metastases (proliferation marker Ki-67, angiogenesis marker CD34, and lymphangiogenesis markers podoplanin and LYVE-1) was assessed by immunohictochemical method in the primary tumor specimens collected during surgery for cutaneous melanoma (40 patients). Proliferative activity of the tumor tissue and volume density of peritumoral blood and lymph vessels increased with increasing tumor malignancy, which could indicate the risk of metastases.

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Authors and Affiliations

  1. Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia

    N. P. Bgatova, Yu. I. Borodin & V. I. Konenkov

  2. Novosibirsk Regional Clinical Oncological Center, Novosibirsk, Russia

    A. I. Lomakin, S. A. Fursov, I. V. Kachesov, S. A. Chepko, N. B. Isakova & V. E. Voytsitsky

Authors
  1. N. P. Bgatova
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  2. A. I. Lomakin
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  3. S. A. Fursov
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  4. I. V. Kachesov
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  5. S. A. Chepko
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  6. N. B. Isakova
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  7. Yu. I. Borodin
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  8. V. E. Voytsitsky
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  9. V. I. Konenkov
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Corresponding author

Correspondence to N. P. Bgatova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 161, No. 4, pp. 532-537, April, 2016

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Bgatova, N.P., Lomakin, A.I., Fursov, S.A. et al. Expression of Molecular Markers of Angiogenesis, Lymphangiogenesis, and Proliferation Depending on the Stage of Skin Melanoma. Bull Exp Biol Med 161, 542–546 (2016). https://doi.org/10.1007/s10517-016-3456-5

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  • DOI: https://doi.org/10.1007/s10517-016-3456-5

Key Words

  • cutaneous melanoma
  • angiogenesis
  • lymphangiogenesis
  • proliferation