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Effect of Linagliptin on Structural Changes in the Kidney in Experimental Type 2 Diabetes Mellitus

Bulletin of Experimental Biology and Medicine volume 161, pages 501–504 (2016)Cite this article

Effect of the dipeptidyl peptidase-4 inhibitor linagliptin on structural manifestations of diabetic nephropathy was studied in BKS.Cg-Dock7m+/+Leprdb/J mice (experimental model of type 2 diabetes mellitus). Linagliptin (10 mg/kg per day) or vehicle was administered by gavage over 8 weeks. Mesangial expansion, thickening of the basement membrane in glomerular capillaries and proximal tubules, and retraction of cytopodia were less pronounced in mice receiving linagliptin. The protective effect of linagliptin on the kidney structure was not associated with its hypoglycemic action.

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Authors and Affiliations

  1. Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia

    Yu. S. Gavrilova, N. P. Bgatova, V. V. Klimontov, I. Yu. Ischenko, S. V. Michurina & N. E. Myakina

  2. Federal Research Center Institute of Cytology and Genetics of Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia

    E. L. Zavyalov

Authors
  1. Yu. S. Gavrilova
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  2. N. P. Bgatova
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  3. V. V. Klimontov
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  4. I. Yu. Ischenko
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  5. S. V. Michurina
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  6. N. E. Myakina
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  7. E. L. Zavyalov
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Correspondence to Yu. S. Gavrilova.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 161, No. 4, pp. 489-493, April, 2016

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Gavrilova, Y.S., Bgatova, N.P., Klimontov, V.V. et al. Effect of Linagliptin on Structural Changes in the Kidney in Experimental Type 2 Diabetes Mellitus. Bull Exp Biol Med 161, 501–504 (2016). https://doi.org/10.1007/s10517-016-3447-6

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  • DOI: https://doi.org/10.1007/s10517-016-3447-6

Key Words

  • type 2 diabetes mellitus
  • diabetic nephropathy
  • linagliptin