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Experimental Evaluation of Biodegradable Film Compositions Based on Gelatin with Colchicine

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Biodegradable film compositions based on natural biopolymer gelatin with immobilized colchicine were prepared and their efficiency in prevention of the adhesion process in the pericardium was evaluated on rabbit model of postoperative pericarditis. The use of gelatin-based biodegradable film compositions significantly reduced the intensity of adhesion formation in the pericardial cavity, while immobilization of anti-inflammatory drug colchicine amplified their anti-adhesion activity.

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References

  1. Alekberova ZS, Barskova VG. Colchicine in rheumatology: yesterday and today. Will there be tomorrow? Sovremen. Revmatol. 2010; (2):25-29. Russian.

  2. Bockeria LA, Bockeria OL, Novikova SP, Salokhedinova RR, Nikolashina LN, Shustrova OV, Sivtsev VS. Studying the properties of the film compositions with gelatin and colchicine. Klin. Fiziol. Krovoobr. 2014; (3):57-66. Russian.

  3. Bockeria LA, Makarenko VN, Zolotaikina OS. Computer tomography potentials in diagnostics of postoperative commissural process in mediastinum. Annaly Khirurgii. 2009; (2):31-34. Russian.

  4. Bockeria LA, Novikova SP, Bockeria OL, Kostrov VI, Salokhedinova RR, Nikolashina LN, Shustrova OV, Sivtsev VS. Film composition gelatin-based structured by different ways. Byull. Nauch. Tsentra Serd.-Sosud. Khirurgii im. A. N. Bakuleva Ross. Akad. Med. Nauk. Serdech.-Sosud. Zabolevaniya. 2014;15(4):60-72. Russian.

  5. Voskanyan SE, Kyzlasov PS. Pathogenesis of adhesions formation after intraabdominal operations. Patol. Fiziol. Eksp. Ter. 2011; (4):17-21. Russian.

  6. Glantz SA, Primer of Biostatistics. Moscow, 1998. Russian.

  7. Kudryavtseva JuA, Nasonova MV, Zhuravleva IJu. Postsurgical adhesion formation in cardiac surgery: problems and perspectives. Patol. Krovoobr. Kardiokhirurgiya. 2011; (1):100-104. Russian.

  8. Alpay Z, Saed GM, Diamond MP. Postoperative adhesions: from formation to prevention. Semin. Reprod. Med. 2008; 26(4):313-321.

    Article  CAS  PubMed  Google Scholar 

  9. Biçer M, Bayram AS, Gürbüz O, Senkaya I, Yerci O, Tok M, Anğ E, Moğol EB, Saba D. Assessment of the efficacy of bioabsorbable oxidized regenerated cellulose for prevention of post-operative pericardial adhesion in the rabbit model. J. Int. Med. Res. 2008; 36(6):1311-1318.

    Article  PubMed  Google Scholar 

  10. Gradus-Pizlo I, Wilensky RL, March KL, Fineberg N, Michaels M, Sandusky GE, Hathaway DR. Local delivery of biodegradable microparticles containing colchicine or a colchicine analogue: effects on restenosis and implications for catheterbased drug delivery. J. Am. Coll. Cardiol. 1995; 26(6):1549-1557.

    Article  CAS  PubMed  Google Scholar 

  11. Heydorn WH, Daniel JS, Wade CE. A new look at pericardial substitutes. J. Thorac. Cardiovasc. Surg. 1987; 94(2):291-296.

    CAS  PubMed  Google Scholar 

  12. Imazio M, Belli R, Brucato A, Ferrazzi P, Patrini D, Martinelli L, Polizzi V, Cemin R, Leggieri A, Caforio AL, Finkelstein Y, Hoit B, Maisch B, Mayosi BM, Oh JK, Ristic AD, Seferovic P, Spodick DH, Adler Y. Rationale and design of the COlchicine for Prevention of the Post-pericardiotomy Syndrome and Post-operative Atrial Fibrillation (COPPS-2 trial): a randomized, placebo-controlled, multicenter study on the use of colchicine for the primary prevention of the postpericardiotomy syndrome, postoperative effusions, and postoperative atrial fibrillation. Am. Heart J. 2013; 166(1):13-19.

  13. Lu JH, Chang Y, Sung HW, Chiu YT, Yang PC, Hwang B. Heparinization on pericardial substitutes can reduce adhesion and epicardial inflammation in the dog. J. Thorac. Cardiovasc. Surg. 1998; 115(5):1111-1120.

    Article  CAS  PubMed  Google Scholar 

  14. Matsumura G, Shin’oka T, Ikada Y, Sakamoto T, Kurosawa H. Novel anti-adhesive pericardial substitute for multistage cardiac surgery. Asian Cardiovasc. Thorac. Ann. 2008; 16(4):309-312.

    Article  PubMed  Google Scholar 

  15. Tsukihara H, Takamoto S, Kitahori K, Matsuda K, Murakami A, Novick RJ, Suematsu Y. Prevention of postoperative pericardial adhesions with a novel regenerative collagen sheet. Ann. Thorac. Surg. 2006; 81(2):650-657.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. A.N. Bakoulev Scientific Center for Cardiovascular Surgery, Moscow, Russia

    L. A. Bokeriya, O. L. Bokeriya, V. S. Sivtsev, S. P. Novikova, R. R. Salokhedinova, L. N. Nikolashina, N. N. Samsonova, A. Yu. Gorodkov & R. A. Serov

Authors
  1. L. A. Bokeriya
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  2. O. L. Bokeriya
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  3. V. S. Sivtsev
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  4. S. P. Novikova
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  5. R. R. Salokhedinova
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  6. L. N. Nikolashina
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  7. N. N. Samsonova
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  8. A. Yu. Gorodkov
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  9. R. A. Serov
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Corresponding author

Correspondence to S. P. Novikova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 161, No. 3, pp. 394-398, March, 2016

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Bokeriya, L.A., Bokeriya, O.L., Sivtsev, V.S. et al. Experimental Evaluation of Biodegradable Film Compositions Based on Gelatin with Colchicine. Bull Exp Biol Med 161, 414–418 (2016). https://doi.org/10.1007/s10517-016-3428-9

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  • DOI: https://doi.org/10.1007/s10517-016-3428-9

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