Immunoreactive uncoupling protein UCP1 was found in the perigonadal fat of only twothirds of 14-week-old male ICR mice. The presence of UCP1 had no effect on the rate of O2 consumption by the adipose tissue. The cellularity of perigonadal fat estimated by the DNA content was significantly higher in tissue containing UCP1 than in samples without this protein. This regularity was also observed after adaptation of mice to moderate cold (10oC) over 8 weeks.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Elsukova EI, Medvedev LN, Kudryavtseva NA. Effect of Semi-Compulsory Alcoholization on Brown Fat in Mice. Bull. Exp. Biol. Med. 2001; 132(6):1145-1146.
Mizonova OV, Elsukova EI, Medvedev LN. Energy Metabolism and Biochemical Features of Adipose Tissues in ICR Mice after Long-Term Calorie-Restricted Diet. Bull. Exp. Biol. Med. 2013; 155(6):745-747.
Trudolyubova MG. Quantitative measurement of RNA and DNA in subcellular fractions of animal cells. Modern methods in biochemistry, Orekhovich VN, ed. Moscow, 1977. pp. 313-316. Russian.
Allan MF, Eisen EJ, Pomp D. The M16 mouse: an outbred animal model of early onset polygenic obesity and diabesity. Obes. Res. 2004; 12(9):1397-1407.
Cinti S. Between brown and white: novel aspects of adipocyte differentiation. Ann. Med. 2011; 43(2):104-115.
Cousin B, Bascands-Viguerie N, Kassis N, Nibbelink M, Ambid L, Casteilla L, Pénicaud L. Cellular changes during cold acclimatation in adipose tissues. J. Cell. Physiol. 1996; 167(2):285-289.
Guerra C, Koza RA, Yamashita H, Walsh K, Kozak LP. Emergence of brown adipocytes in white fat in mice is under genetic control. Effects on body weight and adiposity. J. Clin. Invest. 1998; 102(2):412-420.
Kajimura S, Saito M. A new era in brown adipose tissue biology: molecular control of brown fat development and energy homeostasis. Annu. Rev. Physiol. 2014; 76:225-249.
Li Y, Bolze F, Fromme T, Klingenspor M. Intrinsic differences in BRITE adipogenesis of primary adipocytes from two different mouse strains. Biochim. Biophys. Acta. 2014; 1841(9):1345-1352.
Nedergaard J, Cannon B. UCP1 mRNA does not produce heat. Biochim. Biophys. Acta. 2013; 1831(5):943-949.
Okamatsu-Ogura Y, Fukano K, Tsubota A, Uozumi A, Terao A, Kimura K, Saito M. Thermogenic ability of uncoupling protein 1 in beige adipocytes in mice. PLoS One. 2013; 8(12):e84229.
Villarroya J, Cereijo R, Villarroya F. An endocrine role for brown adipose tissue? Am. J. Physiol. Endocrinol. Metab. 2013; 305(5):E567-E572.
Vitali A, Murano I, Zingaretti MC, Frontini A, Ricquier D, Cinti S. The adipose organ of obesity-prone C57BL/6J mice is composed of mixed white and brown adipocytes. J. Lipid Res. 2012; 53(4):619-629.
Wu J, Cohen P, Spiegelman BM. Adaptive thermogenesis in adipocytes: is beige the new brown? Genes Dev. 2013; 27(3):234-250.
Xue B, Rim JS, Hogan JC, Coulter AA, Koza RA, Kozak LP. Genetic variability affects the development of brown adipocytes in white fat but not in interscapular brown fat. J. Lipid Res. 2007; 48(1):41-51.
Author information
Authors and Affiliations
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 161, No. 3, pp. 321-324, March, 2016
Rights and permissions
About this article
Cite this article
Elsukova, E.I., Medvedev, L.N. & Mizonova, O.V. Physiological Features of Perigonadal Adipose Tissue Containing Uncoupling Protein UCP1 in ICR Mice. Bull Exp Biol Med 161, 347–350 (2016). https://doi.org/10.1007/s10517-016-3411-5
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-016-3411-5