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Expression of Bax Protein and Morphological Changes in the Myocardium in Experimental Acute Pressure Overload of the Left Ventricle

The expression of Bax protein, marker of intracellular pathway of apoptosis initiation, in viable left ventricular cardiomyocytes and morphological changes in the myocardium in acute pressure overload of the left ventricle were studied in experiment on male rabbits. The content of Bax protein in the cardiomyocyte cytoplasm decreased, this indicating that the mitochondrial pathway was not involved in the realization of the apoptotic program. This decrease was associated with manifest destructive changes in the left ventricular myocardium.

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Correspondence to M. M. Azova.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 161, No. 2, pp. 157-160, February, 2016

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Blagonravov, M.L., Korshunova, A.Y., Azova, M.M. et al. Expression of Bax Protein and Morphological Changes in the Myocardium in Experimental Acute Pressure Overload of the Left Ventricle. Bull Exp Biol Med 161, 312–315 (2016). https://doi.org/10.1007/s10517-016-3403-5

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  • DOI: https://doi.org/10.1007/s10517-016-3403-5

Key Words

  • apoptosis
  • Bax
  • acute left ventricular overload
  • cardiomyocyte
  • myocardium