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  • Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
  • Published:

Peptide Regulation of Skin Fibroblast Functions during Their Aging In Vitro

Bulletin of Experimental Biology and Medicine volume 161, pages 175–178 (2016)Cite this article

The effect peptides KE, KED, AED and AEDG on proliferation (Ki-67), regeneration and aging (CD98hc), apoptosis (caspase-3), and extracellular matrix remodeling (MMP-9) in skin fibroblasts during their aging in culture were studied by immunofluorescent confocal microscopy. All studied peptides inhibited MMP-9 synthesis that increases during aging of skin fibroblasts and enhanced the expression of Ki-67 and CD98hc that are less intensively synthesized during cell aging. Peptides AED and AEDG suppressed caspase-dependent apoptosis that increases during aging of cell cultures.

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Authors and Affiliations

  1. St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia

    N. S. Lin’kova, O. A. Orlova, V. O. Polyakova, I. M. Kvetnoy & V. Kh. Khavinson

  2. I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia

    N. S. Lin’kova & V. Kh. Khavinson

  3. Peter the Great St. Petersburg Polytechnical University, St. Petersburg, Russia

    N. S. Lin’kova & E. P. Kuznetsova

  4. D. O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology, St. Petersburg, Russia

    A. O. Drobintseva, V. O. Polyakova & I. M. Kvetnoy

  5. I. I. Mechnikov North-Western State Medical University, St. Petersburg, Russia

    V. Kh. Khavinson

Authors
  1. N. S. Lin’kova
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  2. A. O. Drobintseva
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  3. O. A. Orlova
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  4. E. P. Kuznetsova
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  5. V. O. Polyakova
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  6. I. M. Kvetnoy
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  7. V. Kh. Khavinson
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Corresponding author

Correspondence to N. S. Lin’kova.

Additional information

Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 1, pp. 40-44, January, 2016

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Lin’kova, N.S., Drobintseva, A.O., Orlova, O.A. et al. Peptide Regulation of Skin Fibroblast Functions during Their Aging In Vitro . Bull Exp Biol Med 161, 175–178 (2016). https://doi.org/10.1007/s10517-016-3370-x

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  • DOI: https://doi.org/10.1007/s10517-016-3370-x

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