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Multiwalled Carbon Nanotubules Induce Pathological Changes in the Digestive Organs of Mice

  • A. G. MasyutinEmail author
  • M. V. Erokhina
  • K. A. Sychevskaya
  • A. A. Gusev
  • I. A. Vasyukova
  • A. G. Tkachev
  • E. A. Smirnova
  • G. E. Onishchenko
Article

We studied the effects of regular long-term exposure to industrial nanomaterial based on multiwalled carbon nanotubules on the digestive system of mice. Nanomaterial in a concentration of 30 mg/kg was administered with drinking water over 30 days. Tissue specimens from the small intestine and liver were studied by light and electron microscopy. Multiwalled carbon nanotubules caused multiple necrotic foci in the small intestine and mixed parenchymatous degeneration in the liver. These findings suggested that multiwalled carbon nanotubules entering the digestive tract damaged intestinal villi, presumably via mechanical damage to enterocytes. It seems that multiwalled carbon nanotubules could cause degeneration indirectly, by triggering inflammatory reactions and ROS generation.

Key Words

multiwalled carbon nanotubules enterocyte necrosis liver degeneration 

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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • A. G. Masyutin
    • 1
    Email author
  • M. V. Erokhina
    • 1
  • K. A. Sychevskaya
    • 1
  • A. A. Gusev
    • 2
  • I. A. Vasyukova
    • 2
  • A. G. Tkachev
    • 3
  • E. A. Smirnova
    • 1
  • G. E. Onishchenko
    • 1
  1. 1.M. V. Lomonosov Moscow State UniversityMoscowRussia
  2. 2.Nanotechnologies and Nanomaterials Research and Education CenterG. R. Derzhavin Tambov State UniversityTambovRussia
  3. 3.NanoTechCenterTambovRussia

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