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Studying the Effect of a Composition of the Cluster Core in High-Radiopacity Cluster Complexes of Rhenium on Their Acute Toxicity In Vivo

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An in vivo study was performed to evaluate the dependence of acute toxicity of high-radiopacity and luminescent octahedral cluster complexes of rhenium after intravenous injection on a composition of the cluster core. Changes in mouse body weight, water and food consumption, degree of intoxication, and morphological changes in the visceral organs were studied after intravenous injection of the following cluster complexes with various internal ligands (S, Se, or Te): Na4[{Re 6 Te 8 }(CN)6], Na4[{Re 6 Se 8 }(CN)6], and Na4[{Re 6 S 8 }(CN)6]. The Na4[{Re 6 S 8 } (CN)6] cluster complex was shown to be the safest for animals.

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Authors and Affiliations

  1. Novosibirsk State University, Novosibirsk, Russia

    T. N. Pozmogova, A. A. Krasil’nikova & L. V. Shestopalova

  2. Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russia

    A. A. Krasil’nikova, A. A. Ivanov, M. A. Shestopalov, S. N. Gyrylova, A. M. Shestopaloiv & V. A. Shkurupy

  3. Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia

    T. N. Pozmogova, A. A. Krasil’nikova, A. A. Ivanov & M. A. Shestopalov

  4. A. V. Nikolaev Institute of Inorganic Chemistry, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia

    M. A. Shestopalov

Authors
  1. T. N. Pozmogova
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  2. A. A. Krasil’nikova
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  3. A. A. Ivanov
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  4. M. A. Shestopalov
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  5. S. N. Gyrylova
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  6. L. V. Shestopalova
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  7. A. M. Shestopaloiv
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  8. V. A. Shkurupy
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Corresponding author

Correspondence to M. A. Shestopalov.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 161, No. 1, pp. 75-79, January, 2016

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Pozmogova, T.N., Krasil’nikova, A.A., Ivanov, A.A. et al. Studying the Effect of a Composition of the Cluster Core in High-Radiopacity Cluster Complexes of Rhenium on Their Acute Toxicity In Vivo . Bull Exp Biol Med 161, 64–68 (2016). https://doi.org/10.1007/s10517-016-3346-x

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  • DOI: https://doi.org/10.1007/s10517-016-3346-x

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