Psychopharmacological effects of atisine-type diterpene alkaloid Z77 were studied under conditions of experimental posthypoxic encephalopathy. The preparation had a pronounced cerebroprotective effect consisting in normalization of orientation and exploratory behavior and conditioned activity in experimental animals. These changes were accompanied by significant increase in the number of neural stem cells in the paraventricular region of the brain and markedly enhanced production of neurotrophic growth factors by neural tissue microenvironment cells.
Similar content being viewed by others
References
P. Curzon, M. Zhang, R. J. Radek, and G. B. Fox, The Behavioral Assessment of Sensorimotor Processes in the Mouse: Acoustic Startle, Sensory Gating, Locomotor Activity, Rotarod, and Beam Walking, Methods of Behavior Analysis in Neuroscience, Ed. J. J. Buccafusco, Boca Raton; London; New York (2009), pp. 145-178.
A. M. Dygai, G. N. Zyuz’kov, V. V. Zhdanov, E. V. Udut, L. A. Miroshnichenko, T. Y. Khrichkova, E. V. Simanina, L. A. Stavrova, A. V. Chaikovskiy, T. S. Markova, M. Y. Minakova, V. E. Gol’dberg, A. V. Artamonov, A. A. Bekarev,, G. Madonov, D. N. Kinsht, and R. V. Gurto, Effect of hyaluronidase immobilized using electron-beam synthesis nanotechnology on sensitivity of progenitor cells to regulatory factors. Bull. Exp. Biol. Med., 151, No. 1, 150-153 (2011).
A. M. Dygai, G. N. Zyuz’kov, V. V. Zhdanov,, G. Madonov, E. V. Udut, L. A. Miroshnichenko, T. Y. Khrichkova, E. V. Simanina, L. A. Stavrova, A. V. Artamonov, A. A. Bekarev, D. N. Kinsht, A. V. Chaikovskiy, T. S. Markova, and R. V. Gurto, Pharmacological properties of granulocytic colony-stimulating factor pegylated using electron beam synthesis nanotechnologies. Bull. Exp. Biol. Med., 152, No. 1, 133-137 (2011).
A. M. Dygai, G. N. Zyuz’kov, V. V. Zhdanov, E. V. Udut, L. A. Miroshnichenko, E. V. Simanina, T. Y. Khrichkova, M. Y. Minakova, and, G. Madonov, Specific activity of electronbeam synthesis immobilized hyaluronidase on G-CSF induced mobilization of bone marrow progenitor cells. Stem Cell Rev., 9, No. 2, 140-147 (2013).
E. D. Goldberg, A. M. Dygai, G. N. Zyuz’kov, and V. V. Zhdanov, Mechanisms of mobilization of mesenchymal precursor cell under the effect of granulocytic colony-stimulating factor and hyaluronidase. Bull. Exp. Biol. Med., 144, No. 6, 802-805 (2007)
E. D. Goldberg, A. M. Dygai, G. N. Zyuz’kov, V. V. Zhdanov, E. V. Simanina, and L. A. Gur’yantseva, Role of hyaluronidase in the regulation of functions of mesenchymal precursor cell. Bull. Exp. Biol. Med., 143, No. 4, 548-551 (2007).
G. N. Zyuz’kov, A. V. Chaikovskii, A. A. Ligacheva, V. V. Zhdanov, E. V. Udut, M. G. Danilets, L. A. Miroshnichenko, E. V. Simanina, N. I. Suslov, E. A. Losev, E. S. Trofimova, T. N. Povet’eva, Y. V. Nesterova, T. I. Fomina, M. Y. Minakova, and A. M. Dygai, Role of receptors to fibroblast growth factor (FGF) on mesenchymal precursor cells in the realization of regenerative effects of alkaloid songorine. Bull. Exp. Biol. Med., 157, No. 1, 146-149 (2014).
G. N. Zyuz’kov, M. G. Danilets, A. A. Ligacheva, V. V. Zhdanov, E. V. Udut, L. A. Miroshnichenko, E. V. Simanina, A. V. Chaikovskii, E. S. Trofimova, M. Y. Minakova, V. V. Udut, and A. M. Dygai, PI3K, MAPK EPK1/2 and p38 are involved in the realization of growth potential of mesenchymal progenitor cells under the influence of basic fibroblast growth factor. Bull. Exp. Biol. Med., 157, No. 4, 436-439 (2014).
G. N. Zyuz’kov, M. G. Danilets, A. A. Ligacheva, V. V. Zhdanov, E. V. Udut, L. A. Miroshnichenko, E. V. Simanina, E. S. Trofimova, M. Y. Minakova, A. V. Chaikovskii, V. I. Agafonov, and A. M. Dygai, Role of NF-kB-dependent signaling in the realization of growth potential of mesenchymal progenitor cells in vitro. Bull. Exp. Biol. Med., 155, No. 6, 721-723 (2013).
G. N. Zyuz’kov, A. V. Krapivin, Y. V. Nesterova, T. N. Povetieva, V. V. Zhdanov, N. I. Suslov, T. I. Fomina, E. V. Udut, L. A. Miroshnichenko, E. V. Simanina, A. A. Semenov, S. S. Kravtsova, and A. M. Dygai, Mechanisms of regeneratory effects of baikal aconite diterpene alkaloids. Bull. Exp. Biol. Med., 153, No. 6, 846-850 (2012).
G. N. Zyuz’kov, N. I. Suslov, A. M. Dygai, V. V. Zhdanov, E. D. Gol’dberg, Role of stem cells in adaptation to hypoxia and mechanisms of neuroprotective effect of granulocytic colonystimulating factor. Bull. Exp. Biol. Med., 140, No. 5, 606-611 (2005).
G. N. Zyuz’kov, N. I. Suslov, E. A. Losev, L. A. Ermolaeva, V. V. Zhdanov, E. V. Udut, L. A. Miroshnichenko, E. V. Simanina, V., Demkin, T. N. Povet’eva, Y. V. Nesterova, V. V. Udut, M. Y. Minakova, and A.M. Dygai, Cerebroprotective and regenerative effects of alkaloid Z77 under conditions of brain ischemia. Bull. Exp. Biol. Med., 158, No. 3, 352-355 (2015).
G. N. Zyuz’kov, N. I. Suslov, E. A. Losev, V. V. Zhdanov, E. V. Udut, L. A. Miroshnichenko, E. V. Simanina, T. N. Povet’eva, Y. V. Nesterova, V. V. Udut, M. Y. Minakova, T. A. Zamoshchina, and A. M. Dygai, Mechanisms of psychopharmacological effects of alkaloid Z77 under conditions of brain ischemia. Bull. Exp. Biol. Med., 158, No. 6, 762-765 (2015).
G. N. Zyuz’kov, V. V. Zhdanov, A. M. Dygai, and E. D. Gol’dberg, Role of hyaluronidase in the regulation of hemopoiesis. Bull. Exp. Biol. Med., 144, No. 6, 840-845 (2007).
G. N. Zyuz’kov, V. V. Zhdanov, L. A. Miroshnichenko, E. V. Udut, A. V. Chaikovskii, E. V. Simanina, M. G. Danilets, M. Y. Minakova, V. V. Udut, T. G. Tolstikova, E. E. Shults, L. A. Stavrova, Y. V. Burmina, and A. M. Dygai, Involvement of PI3K, MAPK ERK1/2 and p38 in functional stimulation of mesenchymal progenitor cells by alkaloid songorine. Bull. Exp. Biol. Med., 159, No. 1, 58-61 (2015).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 161, No. 1, pp. 55-59, January, 2016
Rights and permissions
About this article
Cite this article
Zyuz’kov, G.N., Losev, E.A., Chaikovskii, A.V. et al. Psychopharmacological Effects of Alkaloid Z77 under Conditions of Posthypoxic Encephalopathy and Mechanisms of Their Development. Bull Exp Biol Med 161, 45–49 (2016). https://doi.org/10.1007/s10517-016-3341-2
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-016-3341-2