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Role of β-Adrenoceptors and L-Type Ca2+-Channels in the Mechanism of Reperfusion-Induced Heart Injury

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We studied the effects of β-adrenoceptor antagonists propranolol and nadolol and L-type Ca2+-channel blocker verapamil on cardiac reperfusion injury developed after 45-min coronary occlusion. The substances were injected intravenously 5 min before reperfusion. The results indicate that activation of β-adrenoceptors and opening of L-type Ca2+-channels promote the development of cardiac reperfusion injury, while blockage of β-adrenoceptors and/or L-type Ca2+-channels prevents reoxygenation-induced myocardial injury. Propranolol, nadolol, and verapamil can produce infraction-limiting effects after onset of ischemic heart injury.

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Authors and Affiliations

  1. Research Institute of Cardiology, Tomsk, Russia

    Yu. B. Lishmanov, L. N. Maslov & A. V. Mukhomedzyanov

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  1. Yu. B. Lishmanov
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  2. L. N. Maslov
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  3. A. V. Mukhomedzyanov
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Correspondence to L. N. Maslov.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 161, No. 1, pp. 28-31, January, 2016

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Lishmanov, Y.B., Maslov, L.N. & Mukhomedzyanov, A.V. Role of β-Adrenoceptors and L-Type Ca2+-Channels in the Mechanism of Reperfusion-Induced Heart Injury. Bull Exp Biol Med 161, 20–23 (2016). https://doi.org/10.1007/s10517-016-3335-0

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  • DOI: https://doi.org/10.1007/s10517-016-3335-0

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