Analysis of the plasma microRNA profile can be used for the diagnosis of various pathological and physiological conditions. Complete microRNA microprofiling is an extremely important task. Here we used microarray analysis allowing measurement of the expression of 2500 microRNA (MirBase, version 20). About 10% known microRNA were found in the plasma. Most of the detected microRNA (69 microRNA; ~30%) were encoded by mirtrons.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
K. Basso, P. Sumarin, P. Morozov, et al., Immunity, 30, No. 5, 744-752 (2009).
H. J. Curtis, C. R. Sibley, and M. J. Wood, Wiley Interdiscip. Rev. RNA, 3, No. 5, 617-632 (2012).
V. F. Fairbanks, S. C. Ziesmer, and P. C. O’Brien, Clin. Chem., 38, No. 1, 132-140 (1992).
C. Ibanez-Ventoso, M. Vora, and M. Driscoll, PLoS One, 3, No. 7, doi: 10.1371/journal.pone.0002818 (2008).
M. B. Kirschner, S. C. Kao, J. J. Edelman, et al., PLoS One, 6, No. 9, doi: 10.1371/journal.pone.0024145 (2011).
N. Kosaka, H. Iguchi, and T. Ochiya, Cancer Sci., 101, No. 10, 2087-2092 (2010).
E. Ladewig, K. Okamura, A. S. Flynt, et al., Genome Res., 22, No. 9, 1634-1645 (2012).
X. Liu, Y. Wang, Q. Sun, et al., Immunol. Lett., 143, No. 2, 208-217 (2012).
D. V. Maltseva, V. V. Galatenko, T. R. Samatov, et al., BMC Res. Notes., 7, 871 (2014)
F. Pimentel, P. Bonilla, Y. G. Ravishankar, et al., J. Lab. Autom. (2014). pii: 2211068214561788.
C. C. Pritchard, E. Kroh, B. Wood, et al., Cancer Prev. Res. (Phila)., 5, No. 3, 492-497 (2012).
G. Rabinowits, C. Gercel-Taylor, J. M. Day, et al., Clin Lung Cancer, 10, No. 1, 42-46 (2009).
A. G. Tonevitsky, D. V. Maltseva, A. Abbasi, et al., BMC Physiol., 13, 9 (2013)
A. Turchinovich, T.R. Samatov, A. G. Tonevitsky, and B. Burwinkel, Front. Genet., 4, 119 (2013).
J. R. Ward, P. R. Heath, J. W. Catto, et al., PLoS One, 6, No. 1, doi: 10.1371/journal.pone.0015810 (2011).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 160, No. 11, pp. 577-579, November, 2015
Rights and permissions
About this article
Cite this article
Skurnikov, M.Y., Makarova, Y.A., Knyazev, E.N. et al. Profile of microRNA in Blood Plasma of Healthy Humans. Bull Exp Biol Med 160, 632–634 (2016). https://doi.org/10.1007/s10517-016-3235-3
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-016-3235-3