Variability of the Phenotype and Proliferation and Migration Characteristics of Human Mesenchymal Stromal Cells Derived from the Deciduous Teeth Pulp of Different Donors

We performed a comparative study of cell phenotype and proliferation and migration activities in vitro of mesenchymal stromal cells from human exfoliated deciduous teeth (SHED cells) from three donors. In the primary cultures, the cells of different donors had the same morphology and cytophenotype, but differed by proliferative and migration capacities. The results indicate that individual mesenchymal stromal cells cultures can differ considerably by important cell properties, and this should be considered when evaluating their potential therapeutic efficacy and in experimental studies.

This is a preview of subscription content, access via your institution.

References

  1. 1.

    F. P. Daltoe, P.P. Mendonça, A. Mantesso, and M. C. Deboni, Braz. Oral Res., pii: S1806-83242014000100401 (2014).

  2. 2.

    M. Dominici, K. Le Blanc, I. Mueller, et al., Cytotherapy, 8, No. 4, 315-317 (2006).

    CAS  Article  PubMed  Google Scholar 

  3. 3.

    M. Miura, S. Gronthos, M. Zhao, et al., Proc. Natl Acad. Sci. USA, 100, No. 10, 5807-5812 (2003).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  4. 4.

    M. Seifrtova, R. Havelek, T. Soukup, et al., J. Physiol. Pharmacol., 64, No. 2, 255-266 (2013).

    CAS  PubMed  Google Scholar 

  5. 5.

    Torensma R., Prins H.J., E. Schrama, et al., Stem Cells Dev., 22, No. 7, 1086-1096 (2013).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to I. V. Vakhrushev.

Additional information

Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 4, pp. 213-217, October, 2015

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Vakhrushev, I.V., Vdovin, A.S., Strukova, L.A. et al. Variability of the Phenotype and Proliferation and Migration Characteristics of Human Mesenchymal Stromal Cells Derived from the Deciduous Teeth Pulp of Different Donors. Bull Exp Biol Med 160, 525–529 (2016). https://doi.org/10.1007/s10517-016-3212-x

Download citation

Key Words

  • mesenchymal stromal cells
  • dental pulp
  • SHED cells
  • tissue engineering