Variability of the Phenotype and Proliferation and Migration Characteristics of Human Mesenchymal Stromal Cells Derived from the Deciduous Teeth Pulp of Different Donors

Bulletin of Experimental Biology and Medicine volume 160, pages525–529(2016)Cite this article

We performed a comparative study of cell phenotype and proliferation and migration activities in vitro of mesenchymal stromal cells from human exfoliated deciduous teeth (SHED cells) from three donors. In the primary cultures, the cells of different donors had the same morphology and cytophenotype, but differed by proliferative and migration capacities. The results indicate that individual mesenchymal stromal cells cultures can differ considerably by important cell properties, and this should be considered when evaluating their potential therapeutic efficacy and in experimental studies.

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Affiliations

  1. V. N. Orekhovich Research Institute of Biomedical Chemistry, Moscow, Russia

    I. V. Vakhrushev, A. S. Vdovin & K. N. Yarygin

  2. Qvadros-Bio Company, Moscow, Russia

    L. A. Strukova

Authors
  1. I. V. Vakhrushev
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  2. A. S. Vdovin
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  3. L. A. Strukova
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  4. K. N. Yarygin
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Corresponding author

Correspondence to I. V. Vakhrushev.

Additional information

Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 4, pp. 213-217, October, 2015

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Vakhrushev, I.V., Vdovin, A.S., Strukova, L.A. et al. Variability of the Phenotype and Proliferation and Migration Characteristics of Human Mesenchymal Stromal Cells Derived from the Deciduous Teeth Pulp of Different Donors. Bull Exp Biol Med 160, 525–529 (2016). https://doi.org/10.1007/s10517-016-3212-x

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Key Words

  • mesenchymal stromal cells
  • dental pulp
  • SHED cells
  • tissue engineering