Malignant gliomas are most common and fatal primary brain tumors. In addition to neoplastic cells, the tumor tissue contains microglial cells and monocyte-derived macrophages. It is an established fact that monocyte recruiting promotes the tumor growth and dissemination. Monocyte chemotactic protein-1 (MCP-1) is the major attractant for monocytes. We have previously synthesized an MCP-1 antagonist ingramon, a synthetic peptide fragment (65–76) of this chemokine. In the present study, we demonstrated that glioma-conditioned medium contains MCP-1 and stimulates migration of blood monocytes. Ingramon inhibited the effect of glioma-conditioned medium on monocyte migration.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
N. B. Kukhtina, T. I. Arefi eva, and T. L. Krasnikova, Biokhimiya, 70, No. 6, 790–795 (2005).
T. I. Arefi eva, T. L. Krasnikova, A. V. Potekhina, et al., Infl amm. Res., 60, No. 10, 955–964 (2011).
N. A. Charles, E. C. Holland, R. Gilbertson, et al., Glia, 59, No. 8, 1169–1180 (2011).
A. C. da Fonseca and B. Badie, Clin. Dev. Immunol., 2013, 264124 (2013).
I. Desbaillets, M. Tada, N. de Tribolet, et al., Int. J. Cancer., 58, No. 2, 240–247 (1994).
U. M. Domanska, R. C. Kruizinga, W. F. den Dunnen, et al., Crit. Rev. Oncol. Hematol., 79, No. 2, 154–163 (2011).
S. Han, C. Zhang, Q. Li, et al., Br. J. Cancer., 110, No. 10, 2560–2568 (2014).
S. V. Kushchayev, T. Sankar, L. L. Eggink, et al., Cancer Manag. Res., 4, 309–323 (2012).
Y. Lin, G. Zhang, Y. Zhang, et al., J. Neurooncol., 114, No. 2 , 199–208 (2013).
Y. C. Ooi, P. Tran, N. Ung, et al., Clin. Neurol. Neurosurg., 119, 125–132 (2014).
M. Platten, A. Kretz, U. Naumann, et al., Ann. Neurol., 54, No. 3, 388–392 (2003).
C. Vasco, A. Canazza, A. Rizzo, et al., J. Neurooncol., 115, No. 3, 353–363 (2013).
J. Zang, S. Sarkar, R. Cua, et al., Carcinogenesis, 33, No. 2, 312–319 (2012).
X. Zhu, M. Fujita, L. A. Snyder, and H. Okada, J. Neurooncol., 104, No. 1, 83–92 (2011).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 160, No. 10, pp. 484–487, October, 2015
Rights and permissions
About this article
Cite this article
Krasnikova, T.L., Arefieva, T.I., Pylaeva, E.A. et al. Ingramon, a Peptide Inhibitor of MCP-1 Chemokine, Reduces Migration of Blood Monocytes Stimulated by Glioma-Conditioned Medium. Bull Exp Biol Med 160, 480–482 (2016). https://doi.org/10.1007/s10517-016-3201-0
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-016-3201-0