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Assessment of Expression of Genes Coding GABAA Receptors during Chronic and Acute Intoxication of Laboratory Rats with Ethanol

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Expression of genes encoding the individual subunits of ionotropic GABAA receptor was assessed after acute and chronic intoxication of rats with ethanol. The chronic 1-month-long exposure to ethanol signifi cantly decreased (by 38%) expression of Gabrb1 gene in the hippocampus. Acute exposure to ethanol elevated expression of genes Gabrb1 (by 1.7 times), Gabra1 (by 3.8 times), and Gabra4 (by 6.5 times), although it diminished expression of Gabra2 gene by 1.4 times. In preliminarily alcoholized rats, acute intoxication with ethanol enhanced expression of genes Gabrb1 and Gabra5 by 1.7 and 8.7 times, respectively. There was neither acute nor chronic effect of ethanol on expression of gene Gabra3.

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Authors and Affiliations

  1. Institute of Toxicology, Federal Medical-Biological Agency of Russia, St Petersburg, Russia

    N. S. Osechkina, M. B. Ivanov, E. G. Batotsyrenova, N. V. Lapina, A. S. Melekhova, K. O. Voitsekhovich, D. S. Lisitskii & T. V. Kashina

  2. Research and Testing Institute of Military Medicine, S. M. Kirov Military Medical Academy, Ministry of Defense of the Russian Federation, St. Petersburg, Russia

    G. V. Nazarov, A. V. Babkin & I. S. Berdinskikh

Authors
  1. N. S. Osechkina
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  2. M. B. Ivanov
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  3. G. V. Nazarov
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  4. E. G. Batotsyrenova
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  5. N. V. Lapina
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  6. A. V. Babkin
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  7. I. S. Berdinskikh
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  8. A. S. Melekhova
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  9. K. O. Voitsekhovich
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  10. D. S. Lisitskii
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  11. T. V. Kashina
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Corresponding author

Correspondence to N. S. Osechkina.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 160, No. 10, pp. 451-454, October, 2015

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Osechkina, N.S., Ivanov, M.B., Nazarov, G.V. et al. Assessment of Expression of Genes Coding GABAA Receptors during Chronic and Acute Intoxication of Laboratory Rats with Ethanol. Bull Exp Biol Med 160, 452–454 (2016). https://doi.org/10.1007/s10517-016-3194-8

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  • DOI: https://doi.org/10.1007/s10517-016-3194-8

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