We developed and tested a novel hardware-and-software system for recording the amplitude of the acoustic startle response in rodents. In our experiments, the baseline indexes of acoustic startle response in laboratory rats and pre-stimulation inhibition under the standard delivery of acoustic stimulation were similar to those evaluated by other investigators on foreign devices. The proposed system is relatively cheap and provides the possibility of performing experiments on freely moving specimens. It should be emphasized that the results of studies can be processed with free-access software.
Similar content being viewed by others
References
M. I. Maleto, E. F. Pevtsov, and A. S. Sigov, Otkrytoe Obrazovanie, No. 5, 58-66 (2009).
Manual on Preclinical Studies of Medicinal Agents [in Russian], Ed. A. N. Mironov, Moscow (2012), Pt 1.
T. Blumenthal, Startle Modification. Implication for Neuro-science, Cognitive Science and Clinical Science, Eds. M. E. Dawson, et al., Cambridge (1999), pp. 51-71.
F. K. Graham, Attention and Orienting. Sensory and Motivational Processes, Eds. P. J. Lang, et al., Manwah, New Jersey (1997), pp. 417-452.
N. R. Swerdlow and M. A. Geyer, Schizophr. Bull., 24, No. 2, 285-301 (1998).
N. R. Swerdlow, M. Weber, Y. Qu, et al., Psychopharmacology (Berl.), 199, No. 3, 331-388 (2008).
B. Valsamis and S. Schmid, J. Vis. Exp., 55, e3446, doi: 10.3791/3446 (2011).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 160, No. 10, pp. 403-407, October, 2015
Rights and permissions
About this article
Cite this article
Pevtsov, E.F., Storozheva, Z.I., Proshin, A.T. et al. A Hardware-and-Software System for Experimental Studies of the Acoustic Startle Response in Laboratory Rodents. Bull Exp Biol Med 160, 410–413 (2016). https://doi.org/10.1007/s10517-016-3183-y
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-016-3183-y