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Development of Endoplasmic Reticulum Stress during Experimental Oxalate Nephrolithiasis

Bulletin of Experimental Biology and Medicine volume 160, pages 381–385 (2016)Cite this article

Morphological and ultrastructural study of the kidney was performed in rats with oxalate nephrolithiasis. Specific features of endoplasmic reticulum stress were evaluated during nephrolithiasis and treatment with α-tocopherol. We observed the signs of endoplasmic reticulum stress with activation of proapoptotic pathways and injury to the cell lining in nephron tubules and collecting ducts. Ultrastructural changes were found in the organelles, nuclei, and cell membranes of epitheliocytes. A relationship was revealed between endoplasmic reticulum stress and oxidative damage, which developed at the early state of lithogenesis.

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Authors and Affiliations

  1. Institute of Molecular Pathology and Pathomorphology, Novosibirsk, Russia

    G. A. Lapii, E. L. Lushnikova & L. M. Nepomnyashchikh

  2. Altai State Medical University, Barnaul, Russia

    Yu. G. Motin, A. V. Lepilov, A. Yu. Zharikov & N. V. Motina

  3. Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia

    N. P. Bgatova

Authors
  1. Yu. G. Motin
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  2. A. V. Lepilov
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  3. N. P. Bgatova
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  4. A. Yu. Zharikov
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  5. N. V. Motina
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  6. G. A. Lapii
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  7. E. L. Lushnikova
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  8. L. M. Nepomnyashchikh
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Correspondence to Yu. G. Motin.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 160, No. 9, pp. 369-373, September, 2015

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Motin, Y.G., Lepilov, A.V., Bgatova, N.P. et al. Development of Endoplasmic Reticulum Stress during Experimental Oxalate Nephrolithiasis. Bull Exp Biol Med 160, 381–385 (2016). https://doi.org/10.1007/s10517-016-3176-x

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  • DOI: https://doi.org/10.1007/s10517-016-3176-x

Key Words

  • experimental nephrolithiasis
  • endoplasmic reticulum stress
  • α-tocopherol
  • renal epithelium
  • ultrastructure