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Short Peptides and Telomere Length Regulator Hormone Irisin

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Bulletin of Experimental Biology and Medicine Aims and scope

Irisin produced by muscles during exercise and promoting fat burning also exhibits geroprotective effect and induces telomere elongation in normal somatic cells. Special attention is paid to studies of the role of peptides Lys-Glu, Glu-Asp-Arg, and Ala-Glu-Asp-Gly in epigenetic regulation of irisin content. The data suggest that the immunomodulatory peptide Lys-Glu and neuroprotective peptide Glu-Asp-Arg modulate the life span by modulating irisin gene expression.

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Authors and Affiliations

  1. Russian Academy of Sciences, I. P. Pavlov Institute of Physiology, Moskva, Russia

    V. Kh. Khavinson

  2. St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia

    V. Kh. Khavinson, S. I. Tarnovskaya & N. S. Lin’kova

  3. Chita State Medical Academy, Ministry of Health of the Russian Federation, Chita, Russia

    B. I. Kuznik

  4. St. Petersburg State Polytechnological University, St. Petersburg, Russia

    S. I. Tarnovskaya & N. S. Lin’kova

Authors
  1. V. Kh. Khavinson
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  2. B. I. Kuznik
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  3. S. I. Tarnovskaya
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  4. N. S. Lin’kova
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Corresponding author

Correspondence to N. S. Lin’kova.

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Khavinson, V.K., Kuznik, B.I., Tarnovskaya, S.I. et al. Short Peptides and Telomere Length Regulator Hormone Irisin. Bull Exp Biol Med 160, 347–349 (2016). https://doi.org/10.1007/s10517-016-3167-y

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  • DOI: https://doi.org/10.1007/s10517-016-3167-y

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