Antiepileptic activity of a new derivative of benzimidazole RU-1205 was studied on the model of pentylenetetrazole-induced generalized seizures in mice. Sodium valproate was used as the reference substance. RU-1205 was superior to sodium valproate by anticonvulsant activity (by 12 times) and therapeutic index (by 8.5 times). In contrast to sodium valproate, RU-1205 exhibited significant anticonvulsant activity on the model of pentylenetetrazole-induced kindling without tendency to resistance development.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 160, No. 9, pp. 320-323, September, 2015
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Spasov, A.A., Kalitin, K.Y., Grechko, O.Y. et al. Antiepileptic Activity of a New Derivative of Benzimidazole RU-1205. Bull Exp Biol Med 160, 336–339 (2016). https://doi.org/10.1007/s10517-016-3164-1
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DOI: https://doi.org/10.1007/s10517-016-3164-1