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Antiepileptic Activity of a New Derivative of Benzimidazole RU-1205

Bulletin of Experimental Biology and Medicine volume 160, pages 336–339 (2016)Cite this article

Antiepileptic activity of a new derivative of benzimidazole RU-1205 was studied on the model of pentylenetetrazole-induced generalized seizures in mice. Sodium valproate was used as the reference substance. RU-1205 was superior to sodium valproate by anticonvulsant activity (by 12 times) and therapeutic index (by 8.5 times). In contrast to sodium valproate, RU-1205 exhibited significant anticonvulsant activity on the model of pentylenetetrazole-induced kindling without tendency to resistance development.

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Authors and Affiliations

  1. Volgograd State Medical University, Volgograd, Russia

    A. A. Spasov, K. Yu. Kalitin, O. Yu. Grechko & V. A. Anisimova

Authors
  1. A. A. Spasov
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  2. K. Yu. Kalitin
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  3. O. Yu. Grechko
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  4. V. A. Anisimova
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Correspondence to K. Yu. Kalitin.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 160, No. 9, pp. 320-323, September, 2015

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Spasov, A.A., Kalitin, K.Y., Grechko, O.Y. et al. Antiepileptic Activity of a New Derivative of Benzimidazole RU-1205. Bull Exp Biol Med 160, 336–339 (2016). https://doi.org/10.1007/s10517-016-3164-1

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  • DOI: https://doi.org/10.1007/s10517-016-3164-1

Key Words

  • kindling
  • pentylenetetrazole
  • antiepileptic activity
  • anticonvulsant effect
  • epilepsy