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Bulletin of Experimental Biology and Medicine

, Volume 160, Issue 3, pp 336–339 | Cite as

Antiepileptic Activity of a New Derivative of Benzimidazole RU-1205

  • A. A. Spasov
  • K. Yu. KalitinEmail author
  • O. Yu. Grechko
  • V. A. Anisimova
Article
  • 60 Downloads

Antiepileptic activity of a new derivative of benzimidazole RU-1205 was studied on the model of pentylenetetrazole-induced generalized seizures in mice. Sodium valproate was used as the reference substance. RU-1205 was superior to sodium valproate by anticonvulsant activity (by 12 times) and therapeutic index (by 8.5 times). In contrast to sodium valproate, RU-1205 exhibited significant anticonvulsant activity on the model of pentylenetetrazole-induced kindling without tendency to resistance development.

Key Words

kindling pentylenetetrazole antiepileptic activity anticonvulsant effect epilepsy 

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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • A. A. Spasov
    • 1
  • K. Yu. Kalitin
    • 1
    Email author
  • O. Yu. Grechko
    • 1
  • V. A. Anisimova
    • 1
  1. 1.Volgograd State Medical UniversityVolgogradRussia

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