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Role of PI3K, ERK, and p38 Signaling Pathways in the Production of Humoral Erythropoiesis Regulators under Normal Conditions

PI3- and MAP-kinase signaling pathways duplicate and interchange each other in production of agents that determine total erythropoietic activity under conditions of balanced erythropoiesis. The alternative p38-dependent MAP-kinase pathway is the major regulator of erythropoietic activity of adherent bone marrow cells. Blockade of PI3K and p38 signaling pathways stimulated production of erythropoietin by cells that do not produce it constitutively.

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Correspondence to L. A. Miroshnichenko.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 160, No. 7, pp. 21-24, July, 2015

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Dygai, A.M., Zhdanov, V.V., Miroshnichenko, L.A. et al. Role of PI3K, ERK, and p38 Signaling Pathways in the Production of Humoral Erythropoiesis Regulators under Normal Conditions. Bull Exp Biol Med 160, 17–19 (2015). https://doi.org/10.1007/s10517-015-3087-2

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Key Words

  • PI3K
  • ERK1/2
  • p38
  • erythropoietin
  • erythropoietic activity