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Peculiar Effects of Selective Blockade of α2-Adrenoceptor Subtypes on Cardiac Chronotropy in Newborn Rats

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We studied the effects of selective blockade of various subtypes of α2-adrenoceptors on cardiac chronotropy in newborn rats. This period in rats is characterized by the absence of adrenergic regulation of heart function. Blockade of α2A/D- and α2B-adrenoceptors in 1-weekold rats provoked tachycardia. In contrast, blockade of α2C-adrenoceptors in newborn rats had no effect on heart rate.

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Authors and Affiliations

  1. Department of Anatomy, Physiology, and Human Health Protection, Kazan (Volga Region) Federal University, Kazan, Russia

    T. L. Zefirov, L. I. Khisamieva & N. I. Ziyatdinova

  2. Department of Normal Physiology, Kazan Federal Medical University, Kazan, Russia

    A. L. Zefirov

Authors
  1. T. L. Zefirov
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  2. L. I. Khisamieva
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  3. N. I. Ziyatdinova
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  4. A. L. Zefirov
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Correspondence to T. L. Zefirov.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 160, No. 7, pp. 10-12, July, 2015

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Zefirov, T.L., Khisamieva, L.I., Ziyatdinova, N.I. et al. Peculiar Effects of Selective Blockade of α2-Adrenoceptor Subtypes on Cardiac Chronotropy in Newborn Rats. Bull Exp Biol Med 160, 6–8 (2015). https://doi.org/10.1007/s10517-015-3084-5

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  • DOI: https://doi.org/10.1007/s10517-015-3084-5

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