Under conditions of periodic exposures to anxiogenic stress, intensifi cation of LPO in the brain cortex is a glucocorticoid-dependent process. Glucocorticoid receptor antagonist RU38486 prevented increase in monoamine oxidase B activity and content of LPO products of in brain cortex typical of anxiogenic stress. Normalization of LPO intensity under the effect of glucocorticoid receptor antagonist was associated with the correction of stress-induced disturbances.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 159, No. 6, pp. 701-703, June, 2015
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Tseilikman, V.E., Sinitskii, A.I., Tseilikman, O.B. et al. Glucocorticoid-Related Regulation of LPO in Brain Cortex during Anxiogenic Stress. Bull Exp Biol Med 159, 729–731 (2015). https://doi.org/10.1007/s10517-015-3060-0
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DOI: https://doi.org/10.1007/s10517-015-3060-0