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Bulletin of Experimental Biology and Medicine

, Volume 159, Issue 6, pp 718–721 | Cite as

Prospects of Using of κ-Opioid Receptor Agonists U-50,488 and ICI 199,441 for Improving Heart Resistance to Ischemia/Reperfusion

  • S. Yu. Tsibulnikov
  • L. N. Maslov
  • A. V. Mukhomedzyanov
  • A. V. Krylatov
  • M. R. Tsibulnikova
  • Yu. B. Lishmanov
Article

We studied the ability of the agonist of κ1-opioid receptors U-50,488 in doses of 0.1 and 1 mg/kg to simulate ischemic pre- and postconditioning of the heart and κ-opioid receptors ICI 199,441 in a dose of 0.1 mg/kg to simulate the antiarrhythmic effect of heart preconditioning. The duration of ischemia was 10 or 45 min and the duration of reperfusion was 10 min or 2 h. Administration of 1 mg/kg U-50,488 both before ischemia and 5 min before reperfusion produced a pronounced antiarrhythmic effect. U-50,488 injected 5 min before reperfusion 2-fold reduced the ratio of infarction to risk area. Administration of ICI 199,441 in a dose of 0.1 mg/kg 15 min before ischemia produced a potent antiarrhythmic effect. Antiarrhythmic effect of κ-opioid receptor agonists depended on activation of κ-opioid receptors.

Key Words

heart reperfusion κ-opioid receptors postconditioning 

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • S. Yu. Tsibulnikov
    • 1
    • 2
  • L. N. Maslov
    • 1
    • 2
  • A. V. Mukhomedzyanov
    • 1
  • A. V. Krylatov
    • 1
    • 2
  • M. R. Tsibulnikova
    • 2
  • Yu. B. Lishmanov
    • 1
    • 2
  1. 1.Research Institute of CardiologyTomskRussia
  2. 2.National Research Tomsk Polytechnic UniversityTomskRussia

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