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Brattleboro Rats as the Model of Blood Hyperviscosity Syndrome for Testing Substances with Hemorheological Activity

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Hyperviscosity syndrome was described in Brattleboro rats. The aim of this study was to investigate the possibility of Brattleboro rats using, as a test system for the study of agents with hemorheological activity. Under conditions of this model of high blood viscosity syndrome in Brattleboro rats, Lychnis chalcedonica L. extract (150 mg/kg) administered intragastrically for 10 days exhibited hemorheological activity by modulating macro- (plasma viscosity, fibrinogen concentration) and microrheological (erythrocyte aggregation and deformability parameters. Hence, Brattleboro rats are an adequate model of hyperviscosity syndrome that can be used for search and testing of substances with hemorheological activity.

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References

  1. M. B. Plotnikov, L. N. Zibareva, A. A. Koltunov, et al., Rast. Resursy, 34, No. 1, 87-91 (1998).

    Google Scholar 

  2. M. B. Plotnikov, O. I. Aliev, A. S. Vasil’ev, et al., Rast. Resursy, 35, No. 1, 103-107 (1999).

    Google Scholar 

  3. M. B. Plotnikov, O. I. Aliev, M. Yu. Maslov, et al., Eksp. Klin. Farmakol., 63, No. 2, 54-56 (2000).

    CAS  PubMed  Google Scholar 

  4. M. B. Plotnikov, O. I. Aliev, A. S. Vasil’ev, et al., Bull. Exp. Biol. Med., 139, No. 1, 60-63 (2005).

    Article  CAS  PubMed  Google Scholar 

  5. M. B. Plotnikov, N. A. Tyukavina, and T. M. Plotnikova, Diquertin- Based Drugs [in Russian], Tomsk (2005).

  6. M. B. Plotnikov, A. S. Vasil’ev, O. I. Aliev, et al., Biomeditsina, 1, No. 3, 57-62 (2011).

    Google Scholar 

  7. V. Kucukatay, M. Bor-Kucukatay, G. Gundogdu, et al., Folia Biol. (Praha), 58, No. 4, 157-165 (2012).

  8. J. F. Stoltz and M. Donner, Schweiz. Med. Wochenschr., 43, Suppl., 41-49 (1991).

  9. H. Yapislar and E. Taskin, Med. Sci. Monit., 20, No. 1, 399-405 (2014).

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Authors and Affiliations

  1. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia

    M. B. Plotnikov, A. S. Vasil’ev & O. I. Aliev

  2. National Research Tomsk State University, Tomsk, Russia

    M. B. Plotnikov, O. I. Aliev & L. N. Zibareva

Authors
  1. M. B. Plotnikov
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  2. A. S. Vasil’ev
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  3. O. I. Aliev
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  4. L. N. Zibareva
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Corresponding author

Correspondence to M. B. Plotnikov.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 159, No. 5, pp. 653-655, May, 2015

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Plotnikov, M.B., Vasil’ev, A.S., Aliev, O.I. et al. Brattleboro Rats as the Model of Blood Hyperviscosity Syndrome for Testing Substances with Hemorheological Activity. Bull Exp Biol Med 159, 689–691 (2015). https://doi.org/10.1007/s10517-015-3048-9

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  • DOI: https://doi.org/10.1007/s10517-015-3048-9

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