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Histological Changes in Pancreatic Islets of Animals with Experimental Diabetes Caused by Xanthurenic Acid under Condition of Suppression of Its Endogenous Synthesis

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Long-term administration of pyridoxine to rats kept on a diabetogenic diet stimulating endogenous synthesis of xanthurenic acid resulted in minimal glycemia, less pronounced decrease in insulin content in β-cells, and more intensive excretion of xanthurenic acid with urine. Histological changes were observed in 23% pancreatic islets, whereas in rats not treated with pyridoxine, destruction and necrosis of 40-45% β-cells were found in 38% of studied islets.

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Authors and Affiliations

  1. Diabetes Research Group E.A. Buketov Karaganda State University, Karaganda, Republic of Kazakhstan

    G. G. Meyramov, К.-D. Kohnert, А. А. Kikimbaeva, А. М. Аitkulov, Z. T. Кystaubaeva, O.-N. Dupont, Е. М. Laryushina & А. G. Меyramova

  2. E.A. Buketov Karaganda State University, Karaganda, Republic of Kazakhstan

    G. G. Meyramov, А. М. Аitkulov, Z. T. Кystaubaeva, G. M. Тykeshanova, А. G. Меyramova, G. O. Zhuzbaeva, О. L. Коvalenko & A. S. Shaybek

  3. Institut für Diabetes “Gerhardt Katsch”, Karlsburg, Germany

    К.-D. Kohnert

Authors
  1. G. G. Meyramov
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  2. К.-D. Kohnert
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  3. А. А. Kikimbaeva
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  4. А. М. Аitkulov
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  5. Z. T. Кystaubaeva
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  6. G. M. Тykeshanova
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  7. O.-N. Dupont
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  8. Е. М. Laryushina
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  9. А. G. Меyramova
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  10. G. O. Zhuzbaeva
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  11. О. L. Коvalenko
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  12. A. S. Shaybek
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Corresponding author

Correspondence to G. G. Meyramov.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 159, No. 5, pp. 643–648, May, 2015

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Meyramov, G.G., Kohnert, КD., Kikimbaeva, А.А. et al. Histological Changes in Pancreatic Islets of Animals with Experimental Diabetes Caused by Xanthurenic Acid under Condition of Suppression of Its Endogenous Synthesis. Bull Exp Biol Med 159, 680–684 (2015). https://doi.org/10.1007/s10517-015-3046-y

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  • DOI: https://doi.org/10.1007/s10517-015-3046-y

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