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Evaluation of the Effect of Modified Bioflavonoid and Quercetin Dihydrate on Cytokine Secretion by Mitogen-Activated Mononuclear Cells

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An experimental study revealed the effect on modified bioflavonoid on the inhibition of secretion of IFN-γ and IL-2 by ConA-stimulated mononuclear cells. These changes were accompanied by an increase in the secretion of IL-17 and IL-6. Our results suggest the differentiation of CD4+ T helper cells into Th1 and Th17 subpopulations. The reference drug quercetin dihydrate induced an insignificant change in the level of IL-2 and IL-6 and small increase in IFN-γ content. The content of IL-17 was shown to decrease above the detection limit.

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Authors and Affiliations

  1. Department of Pharmacology, N. I. Pirogov Russian National Research, Medical University, Ministry of Health of the Russian Federation, Moscow, Russia

    D. Z. Albegova, O. V. Kamkina & I. G. Kozlov

  2. D. Rogachev Federal Research and Clinical Center of Pediatric Hematology, Oncology, and Immunology, Moscow, Russia

    O. S. Laptev & I. G. Kozlov

  3. I. N. Ulyanov, Chuvash State University, Cheboksary, Russia

    S. I. Pavlova

  4. North Ossetian State Medical Academy, Ministry of Health of the Russian Federation, Vladikavkaz, Russia

    Zh. K. Albegova

Authors
  1. D. Z. Albegova
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  2. O. V. Kamkina
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  3. S. I. Pavlova
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  4. Zh. K. Albegova
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  5. O. S. Laptev
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  6. I. G. Kozlov
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Corresponding author

Correspondence to O. V. Kamkina.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 159, No. 5, pp. 584-586, May, 2015

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Albegova, D.Z., Kamkina, O.V., Pavlova, S.I. et al. Evaluation of the Effect of Modified Bioflavonoid and Quercetin Dihydrate on Cytokine Secretion by Mitogen-Activated Mononuclear Cells. Bull Exp Biol Med 159, 626–628 (2015). https://doi.org/10.1007/s10517-015-3031-5

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  • DOI: https://doi.org/10.1007/s10517-015-3031-5

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