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Evaluation of the Effect of Modified Bioflavonoid and Quercetin Dihydrate on Cytokine Secretion by Mitogen-Activated Mononuclear Cells

An experimental study revealed the effect on modified bioflavonoid on the inhibition of secretion of IFN-γ and IL-2 by ConA-stimulated mononuclear cells. These changes were accompanied by an increase in the secretion of IL-17 and IL-6. Our results suggest the differentiation of CD4+ T helper cells into Th1 and Th17 subpopulations. The reference drug quercetin dihydrate induced an insignificant change in the level of IL-2 and IL-6 and small increase in IFN-γ content. The content of IL-17 was shown to decrease above the detection limit.

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Correspondence to O. V. Kamkina.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 159, No. 5, pp. 584-586, May, 2015

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Albegova, D.Z., Kamkina, O.V., Pavlova, S.I. et al. Evaluation of the Effect of Modified Bioflavonoid and Quercetin Dihydrate on Cytokine Secretion by Mitogen-Activated Mononuclear Cells. Bull Exp Biol Med 159, 626–628 (2015). https://doi.org/10.1007/s10517-015-3031-5

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  • DOI: https://doi.org/10.1007/s10517-015-3031-5

Key Words

  • flavonoids
  • cytokines
  • mononuclear cells