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Thymus Polypeptide Preparation Tactivin Restores Learning and Memory in Thymectomied Rats

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Bulletin of Experimental Biology and Medicine Aims and scope

We studied the effects of tactivin and splenic polypeptides on learning and memory of thymectomized animals. In 3-week rats, thymectomy blocked active avoidance conditioning. Injections of tactivin (0.5 mg/kg) during 1 month after surgery restored learning capacity; splenic polypeptides were ineffective.

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Authors and Affiliations

  1. Department of Higher Nervous Activity, Biological Faculty, M. V. Lomonosov, Moscow State University, Moscow, Russia

    A. V. Novoseletskaya & A. N. Inozemtsev

  2. Department of Pharmacology,Pediatric Faculty, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia

    N. M. Kiseleva

  3. Laboratory of Molecular Immunology and Biochemistry, Research Institute of Physicochemical Medicine, Federal Medical-and-Biological Agency of Russia, Moscow, Russia

    N. M. Kiseleva, I. V. Zimina, O. V. Bystrova, O. V. Belova, V. Ya. Arion & V. I. Sergienko

Authors
  1. A. V. Novoseletskaya
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  2. N. M. Kiseleva
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  3. I. V. Zimina
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  4. O. V. Bystrova
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  5. O. V. Belova
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  6. A. N. Inozemtsev
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  7. V. Ya. Arion
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  8. V. I. Sergienko
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Corresponding author

Correspondence to A. V. Novoseletskaya.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 159, No. 5, pp. 580-583, May, 2015

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Novoseletskaya, A.V., Kiseleva, N.M., Zimina, I.V. et al. Thymus Polypeptide Preparation Tactivin Restores Learning and Memory in Thymectomied Rats. Bull Exp Biol Med 159, 623–625 (2015). https://doi.org/10.1007/s10517-015-3030-6

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  • DOI: https://doi.org/10.1007/s10517-015-3030-6

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