Antianxiety action of diterpene alkaloid songorine was studied using Vogel conflict test. Songorine in a dose of 0.25 mg/kg demonstrated high anxiolytic activity comparable to that of phenazepam and produced no sedative effect.
Similar content being viewed by others
References
N. G. Buldakova, Russ. Med. Zh., 21, 1516-1519 (2006).
O. V. Vorob’eva, Russ. Med. Zh., 23, 1696-1699 (2006).
T. A. Klygul’ and V. A. Krivopalov, Farmakol. Toksikol., 2, 241-244 (1966)
M. D. Mashkovskii, Drugs, Moscow (2008).
Yu. V. Nesterova, T. N. Povetieva, N. I. Suslov et al., Bull. Exp. Biol. Med., 156, No. 5, 665-668 (2014).
Yu. V. Nesterova, T. N. Povet’eva, N. I. Suslov et al., Vopr. Biol., Med. Farm. Khimii, 8, No. 10, 44-48 (2010).
Yu. V. Nesterova, T. N. Povetiyeva, N. I. Suslov et al., Bull. Exp. Biol. Med., 157, No. 4, 488-491 (2014).
T. N. Povet’eva, V. G. Pashinskii, Yu. V. Nesterova et al., Sib. Onkol., Zh., No. 4, 43-46 (2005).
Guidelines for Preclinical Studies of Drugs, Ed. A. N. Mironov, Moscow, Part 1 (2012).
C. Barbui, A. Cipriani, V. Patel, et al., Br. J. Psychiatry, 198, No. 1, 11-16 (2011).
G. Fricchione, N. Engl. J. Med., 351, No. 7, 675-682 (2004).
Y. V. Nesterova, T. N. Povetieva, N. I. Suslov, et al., Bull. Exp. Biol. Med., 152, No. 4, 439-443 (2012).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 159, No. 5, pp. 577-579, May, 2015
Rights and permissions
About this article
Cite this article
Nesterova, Y.V., Povet’eva, T.N., Suslov, N.I. et al. Anxiolytic Activity of Diterpene Alkaloid Songorine. Bull Exp Biol Med 159, 620–622 (2015). https://doi.org/10.1007/s10517-015-3029-z
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-015-3029-z