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Antioxidant Action of Apelin-12 Peptide and Its Structural Analog In Vitro

  • BIOPHYSICS AND BIOCHEMISTRY
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Bulletin of Experimental Biology and Medicine Aims and scope

The effects of C-terminal fragment of natural peptide apelin-12 H-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-OH (A12) and its structural analog H-(NαMe)Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Nle-Pro-Phe-OH (AI) on Cu2+-induced free radical oxidation of low-density lipoprotein in human blood plasma and activity of commercially available enzymes superoxide dismutase and catalase in a concentration range of 0.01-1 mM were examined. A12 and AI had no effect on superoxide dismutase and catalase activities during 24-h co-incubation with these enzymes at 4°C. When used in a concentration of 1 mM, A12 and AI decreased the maximum low-density lipoprotein oxidation rate by 51 and 47%, respectively, and lengthened the lag phase of low-density lipoprotein oxidation by 2.6 and 1.8 times, respectively, which confirmed their antioxidant potency.

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Authors and Affiliations

  1. Russian Cardiology Research-and-Production Complex, Ministry of Health of the Russian Federation, Moscow, Russia

    Y. A. Pelogeykina, G. G. Konovalova, O. I. Pisarenko & V. Z. Lankin

Authors
  1. Y. A. Pelogeykina
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  2. G. G. Konovalova
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  3. O. I. Pisarenko
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  4. V. Z. Lankin
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Corresponding author

Correspondence to Y. A. Pelogeykina.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 159, No. 5, pp. 557-560, May, 2015

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Pelogeykina, Y.A., Konovalova, G.G., Pisarenko, O.I. et al. Antioxidant Action of Apelin-12 Peptide and Its Structural Analog In Vitro . Bull Exp Biol Med 159, 604–606 (2015). https://doi.org/10.1007/s10517-015-3024-4

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  • DOI: https://doi.org/10.1007/s10517-015-3024-4

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