The dynamics of systolic and diastolic BP and vasodilatory activity of the endothelium in SHR and Wistar-Kyoto rats was studied from the 5th to the 12th week of life. Systolic and diastolic BP did not differ in 5-week-old SHR and Wistar-Kyoto rats. After the 6th week of life, two stages of arterial hypertension development were observed in SHR. Stage 1 (weeks 6-8) was characterized by a significant increase in systolic and diastolic BP that exceeded the corresponding parameters in Wistar-Kyoto rats by 26-32%. Vasodilatory activity of the endothelium was similar in rats of both strains at the age of 5-7 weeks. Stage 2 (weeks 9-12) in SHR rats was characterized by further increase in systolic and diastolic BP that exceeded the corresponding parameters in Wistar-Kyoto rats by 54-89%. The increase in BP during this period was accompanied by a significant decrease in endothelium-dependent relaxation (by 14-16% compared to that in Wistar-Kyoto rats of the same age).
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
D. A. Zhuravlev, Arterial. Giperten., 15, No. 6, 721-723 (2009).
Y. Akiba, N. Yamaguchi, H. Amano, et al., Clin. Exp. Pharmacol. Physiol. Suppl., 22, No. 1, S142-S143 (1995).
J. W. Boylan, J. B. Van Liew, and P. U. Feig, Proc. Natl Acad. Sci. USA, 88, No. 21, 9848-9852 (1991).
G. Bruschi, M. Minari, M. E. Bruschi, et al., Hypertension, 8, No. 11, 983-989 (1986).
A. Chabanel, D. Schachter, and S. Chien, Hypertension, 10, No. 6, 603-607 (1987).
T. C. Chou, M. H. Yen, C. Y. Li, and Y. A. Ding, Hypertension, 31, No. 2, 643-648 (1998).
K. Dharmashankar and M. E. Widlansky, Curr. Hypertens., 12, No. 6, 448-455 (2010).
F. Li and I. G. Joshua, Clin. Exp. Hypertens., 15, No. 3, 511-526 (1993).
P. Puddu, G. M. Puddu, F. Zaca, and A. Muscari, Acta Cardiol., 55, No. 4, 221-232 (2000).
J. W. Rush and R. J. Ford, Clin. Hemorheol. Microcirc., 37, Nos. 1-2, 185-192 (2007).
M. Safar, P. Chamiot-Clerc, G. Dagher, and J. F. Renaud, Hypertension, 38, No. 6, 1416-1421 (2001).
M. Tominaga, K. Fujii, I. Abe, et al., J. Hypertens., 12, No. 3, 259-268 (1994).
H. Vapaatalo, E. Mervaala, and M. L. Nurminen, Physiol. Res., 49, No. 1, 1-10 (2000).
N. D. Vaziri, Z. Ni, F. Oveisi, et al., Hypertension, 31, No. 6, 1248-1254 (1998).
J. Zicha and J. Kunes, Physiol. Rev., 79, No. 4, 1227-1282 (1999).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 159, No. 5, pp. 541-544, May, 2015
Rights and permissions
About this article
Cite this article
Anishchenko, A.M., Aliev, O.I., Sidekhmenova, A.V. et al. Dynamics of Blood Pressure Elevation and Endothelial Dysfunction in SHR Rats During the Development of Arterial Hypertension. Bull Exp Biol Med 159, 591–593 (2015). https://doi.org/10.1007/s10517-015-3020-8
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-015-3020-8