In mouse motor synapses, a non-selective purinoceptor antagonist suramin increased the quantum content of endplate potentials (EPP) without changing the time course of synaptic potentials. An ectonucleotidase inhibitor ARL 67156 had no effect on the amplitude and quantum content of EPP and miniature endplate potentials (mEPP) evoked by single stimuli, but significantly prolonged their duration. Long-term high-frequency stimulation of the nerve in the presence of ARL 67156 persistently increased the amplitude and duration of EPP during the train of impulses, but did not change their quantum content. ATP-γ-S, a non-hydrolyzed ATP analogue, significantly increased the amplitudes and prolonged the rising and falling phases of EPP and mEPP. The ATP-induced postsynaptic potentiation in neuromuscular transmission can result from the increase in ATP content and its longer presence in the synaptic cleft.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
G. Burnstock, Physiol. Rev., 87, No. 2, 659-797 (2007).
C. C. Chen, A. N. Akopian, L. Sivilotti, et al., Nature, 377, 428-431 (1995).
R. A. Cunha, E. S. Vizi, J. F. Ribeiro, and A. M. Sebastião, J. Neurochem., 67, No. 5, 2180-2187 (1996).
P. Ghildyal, D. Palani, and R. Manchanda, J. Physiol. 575, Pt 2, 469-480 (2006).
A. R. Giniatullin, S. N. Grishin, E. R. Sharifullina, et al., J. Physiol., 565, Pt 1, 229-242 (2005).
R. A. Giniatullin and E. M. Sokolova, Br. J. Pharmacol., 124, No. 4, 839-844 (1998).
R. A. Giniatullin, R. N. Khazipov, and F. Vyskocil, J. Physiol., 466, 95-103 (1993).
C. H. Hoyle, G. E. Knight, and G. Burnstock, Br. J. Pharmacol., 99, No. 3, 617-621 (1990).
Z. Lu and D. O. Smith, J. Physiol., 436, 45-56 (1991).
M. A. Riquelme, L. A. Cea, J. L. Vega, et al., Neuropharmacology, 75, 594-603 (2013).
P. Sneddon, T. D. Westfall, L. D. Todorov, et al., Br. J. Pharmacol., 129, No. 6, 1089-1094 (2000).
E. Sokolova, S. Grishin, A. Shakirzyanova, et al., Eur. J. Neurosci., 18, No. 5, 1254-1264 (2003).
B. Sperlagh, A. Heinrich, and C. Csölle, Purinergic Signal., 3, No. 4, 269-284 (2007).
A. A. Voss, J. Physiol., 587, Pt 23, 5739-5752 (2009).
H. Zimmermann, M. Zebisch, and N. Strater, Purinergic Signal., 8, No. 3, 437-502 (2012).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 159, No. 5, pp. 532-536, May, 2015
Rights and permissions
About this article
Cite this article
Bogacheva, P.O., Balezina, O.P. Postsynaptic Potentiation in Mouse Motor Synapses Induced by ATP Accumulation in Synaptic Cleft. Bull Exp Biol Med 159, 583–587 (2015). https://doi.org/10.1007/s10517-015-3018-2
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-015-3018-2