TNFα inhibited proliferation and did not inhibit migration JEG-3 trophoblast cells, IL-1β stimulated both cell proliferation and migration, IL-6 and IL-8 stimulated only cell migration, IFNγ has either stimulating or inhibitory effect on proliferation of trophoblast cells depending on its concentration. Cytokines IL-10 and IL-4 stimulated only migration of trophoblast cells. VEGF, PlGF, and TGFβ stimulated both proliferation and migration, and bFGF only migration of trophoblast cells.
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Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 2, pp. 95–102, April, 2015
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Sokolov, D.I., Furaeva, K.N., Stepanova, O.I. et al. Proliferative and Migration Activity of JEG-3 Trophoblast Cell Line in the Presence of Cytokines. Bull Exp Biol Med 159, 550–556 (2015). https://doi.org/10.1007/s10517-015-3013-7
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DOI: https://doi.org/10.1007/s10517-015-3013-7